@inbook{f914b5a9e4e946ada674923ea58ae5ce,
title = "Obesity, Senescence, and Senolytics",
abstract = "Obesity is a major risk factor for the development of comorbidities such as type 2 diabetes, neurodegenerative disorders, osteoarthritis, cancer, cardiovascular and renal diseases. The onset of obesity is linked to an increase of senescent cells within adipose tissue and other organs. Cellular senescence is a stress response that has been shown to be causally linked to aging and development of various age-related diseases such as obesity. The senescence-associated-secretory phenotype of senescent cells creates a chronic inflammatory milieu that leads to local and systemic dysfunction. The elimination of senescent cells using pharmacological approaches (i.e., senolytics) has been shown to delay, prevent, or alleviate obesity-related organ dysfunction.",
keywords = "Adipose tissue, Cellular senescence, Obesity, SASP, Senolytics",
author = "Selim Chaib and Tamara Tchkonia and Kirkland, {James L.}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2022",
doi = "10.1007/164_2021_555",
language = "English (US)",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "165--180",
booktitle = "Handbook of Experimental Pharmacology",
}