Obesity, metabolic syndrome, and airway disease: A bioenergetic problem?

Anurag Agrawal, Y. S. Prakash

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Multiple studies have determined that obesity increases asthma risk or severity. Metabolic changes of obesity, such as diabetes or insulin resistance, are associated with asthma and poorer lung function. Insulin resistance is also found to increase asthma risk independent of body mass. Conversely, asthma is associated with abnormal glucose and lipid metabolism, insulin resistance, and obesity. Here we review our current understanding of how dietary and lifestyle factors lead to changes in mitochondrial metabolism and cellular bioenergetics, inducing various components of the cardiometabolic syndrome and airway disease.

Original languageEnglish (US)
Pages (from-to)785-796
Number of pages12
JournalImmunology and Allergy Clinics of North America
Volume34
Issue number4
DOIs
StatePublished - 2014

Keywords

  • Arginine
  • Asthma
  • Bioenergetics
  • Metabolic syndrome
  • Metformin
  • Mitochondria
  • Reactive oxygen species
  • Statin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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