Nuclear microenvironments in biological control and cancer

Sayyed K. Zaidi, Daniel W. Young, Amjad Javed, Jitesh Pratap, Martin Montecino, Andre Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalReview article

122 Scopus citations

Abstract

Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalNature Reviews Cancer
Volume7
Issue number6
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Zaidi, S. K., Young, D. W., Javed, A., Pratap, J., Montecino, M., Van Wijnen, A., Lian, J. B., Stein, J. L., & Stein, G. S. (2007). Nuclear microenvironments in biological control and cancer. Nature Reviews Cancer, 7(6), 454-463. https://doi.org/10.1038/nrc2149