Nuclear Matrix Acceptor Binding Sites for Steroid Hormone Receptors: A Candidate Nuclear Matrix Acceptor Protein

Andrea H. Lauber, Nicole P. Sandhu, Mark Schuchard, M. Subramaniam, Thomas C. Spelsberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Steroid/nuclear-hormone receptors are ligand-activated transcription factors that have been localized to the nuclear matrix. The classic model of hormone action suggests that, following activation, these receptors bind to specific „steroid response elements” on the DNA, then interact with other factors in the transcription initiation complex. However, evidence demonstrates the existence of specific chromatin proteins that act as accessory factors by facilitating the binding of the steroid receptors to the DNA. One such protein, the „receptor binding factor (RBF)-1 ”, has been purified and shown to confer specific, high-affinity binding of the progesterone receptor to the DNA. Interestingly, the RBF-1 is localized to the nuclear matrix. Further, the RBF-1 binds specifically to a sequence of the c-myc proto-oncogene that has the appearance of a nuclear matrix attached region (MAR). These results, and other findings reviewed here, suggest that the nuclear matrix is involved intimately in steroid hormone-regulated gene expression.

Original languageEnglish (US)
Pages (from-to)337-376
Number of pages40
JournalInternational Review of Cytology
Volume162
Issue numberPB
DOIs
StatePublished - Jan 1 1996

Keywords

  • Acceptor protein
  • Matrix-attached region
  • Progesterone receptor
  • Receptor binding factor-1
  • Steroid hormone
  • c-myc proto-oncogene

ASJC Scopus subject areas

  • Histology
  • Cell Biology

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