Novel roles of the unfolded protein response in the control of tumor development and aggressiveness

Nicolas Dejeans, Kim Barroso, Martin E Fernandez-Zapico, Afshin Samali, Eric Chevet

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalSeminars in Cancer Biology
Volume33
DOIs
StatePublished - Aug 1 2015

Fingerprint

Unfolded Protein Response
Secretory Pathway
Neoplasms
Membrane Proteins
Homeostasis
Phenotype

Keywords

  • Cancer
  • EMT
  • Endoplasmic reticulum
  • Stress
  • Tumor

ASJC Scopus subject areas

  • Cancer Research

Cite this

Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. / Dejeans, Nicolas; Barroso, Kim; Fernandez-Zapico, Martin E; Samali, Afshin; Chevet, Eric.

In: Seminars in Cancer Biology, Vol. 33, 01.08.2015, p. 67-73.

Research output: Contribution to journalArticle

@article{a1235dcac1bf4ad09a0f406509fe2ca5,
title = "Novel roles of the unfolded protein response in the control of tumor development and aggressiveness",
abstract = "The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness.",
keywords = "Cancer, EMT, Endoplasmic reticulum, Stress, Tumor",
author = "Nicolas Dejeans and Kim Barroso and Fernandez-Zapico, {Martin E} and Afshin Samali and Eric Chevet",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.semcancer.2015.04.007",
language = "English (US)",
volume = "33",
pages = "67--73",
journal = "Seminars in Cancer Biology",
issn = "1044-579X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Novel roles of the unfolded protein response in the control of tumor development and aggressiveness

AU - Dejeans, Nicolas

AU - Barroso, Kim

AU - Fernandez-Zapico, Martin E

AU - Samali, Afshin

AU - Chevet, Eric

PY - 2015/8/1

Y1 - 2015/8/1

N2 - The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness.

AB - The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness.

KW - Cancer

KW - EMT

KW - Endoplasmic reticulum

KW - Stress

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=84938203694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938203694&partnerID=8YFLogxK

U2 - 10.1016/j.semcancer.2015.04.007

DO - 10.1016/j.semcancer.2015.04.007

M3 - Article

C2 - 25953433

AN - SCOPUS:84938203694

VL - 33

SP - 67

EP - 73

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

SN - 1044-579X

ER -