Novel PEGylated amphiphilic copolymers as nanocarriers for drug delivery: Synthesis, characterization and curcumin encapsulation

Vijayendra Kumar, Bhavna Gupta, Gaurav Kumar, Mukesh K. Pandey, Eric Aiazian, Virinder S. Parmar, Jayant Kumar, Arthur C. Watterson

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Amphiphilic polymers can self assemble into micellar nano-particles and can be effectively used as nano carriers for drug delivery. A number of macromolecular delivery systems are under investigation to improve the efficacy of prospective drugs. In this study, seven new co-polymers were synthesized under mild reaction conditions in bulk (without solvent) by chemoenzymatic approach using Candida antarctica lipase (Novozyme 435) and molecular sieves, subsequently these polymers were treated with different long chain bromoalkanes and acid chlorides for attachment of the lipophilic moieties to the backbone polymer via an ether or an ester linkage, respectively in order to make them amphiphilic. These synthesized nano-particles demonstrated high drug loading capacity and have the potential to encapsulate hydrophobic drugs.

Original languageEnglish (US)
Pages (from-to)1154-1160
Number of pages7
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume47
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • EGylated amphiphilic copolymers
  • curcumin encapsulation
  • drug delivery
  • nanocarriers

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

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