Novel PEGylated amphiphilic copolymers as nanocarriers for drug delivery: Synthesis, characterization and curcumin encapsulation

Vijayendra Kumar; Bhavna Gupta; Gaurav Kumar; Mukesh K. Pandey; Eric Aiazian; Virinder S. Parmar; Jayant Kumar; Arthur C. Watterson

doi:10.1080/10601325.2010.518549

Novel PEGylated amphiphilic copolymers as nanocarriers for drug delivery: Synthesis, characterization and curcumin encapsulation

Vijayendra Kumar, Bhavna Gupta, Gaurav Kumar, Mukesh K. Pandey, Eric Aiazian, Virinder S. Parmar, Jayant Kumar, Arthur C. Watterson

Radiology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Amphiphilic polymers can self assemble into micellar nano-particles and can be effectively used as nano carriers for drug delivery. A number of macromolecular delivery systems are under investigation to improve the efficacy of prospective drugs. In this study, seven new co-polymers were synthesized under mild reaction conditions in bulk (without solvent) by chemoenzymatic approach using Candida antarctica lipase (Novozyme 435) and molecular sieves, subsequently these polymers were treated with different long chain bromoalkanes and acid chlorides for attachment of the lipophilic moieties to the backbone polymer via an ether or an ester linkage, respectively in order to make them amphiphilic. These synthesized nano-particles demonstrated high drug loading capacity and have the potential to encapsulate hydrophobic drugs.

Original language	English (US)
Pages (from-to)	1154-1160
Number of pages	7
Journal	Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume	47
Issue number	12
DOIs	https://doi.org/10.1080/10601325.2010.518549
State	Published - Dec 2010

Keywords

EGylated amphiphilic copolymers
curcumin encapsulation
drug delivery
nanocarriers

ASJC Scopus subject areas

Ceramics and Composites
General Chemistry
Polymers and Plastics
Materials Chemistry

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Kumar, V., Gupta, B., Kumar, G., Pandey, M. K., Aiazian, E., Parmar, V. S., Kumar, J., & Watterson, A. C. (2010). Novel PEGylated amphiphilic copolymers as nanocarriers for drug delivery: Synthesis, characterization and curcumin encapsulation. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 47(12), 1154-1160. https://doi.org/10.1080/10601325.2010.518549

Kumar, V, Gupta, B, Kumar, G, Pandey, MK, Aiazian, E, Parmar, VS, Kumar, J & Watterson, AC 2010, 'Novel PEGylated amphiphilic copolymers as nanocarriers for drug delivery: Synthesis, characterization and curcumin encapsulation', Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, vol. 47, no. 12, pp. 1154-1160. https://doi.org/10.1080/10601325.2010.518549

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abstract = "Amphiphilic polymers can self assemble into micellar nano-particles and can be effectively used as nano carriers for drug delivery. A number of macromolecular delivery systems are under investigation to improve the efficacy of prospective drugs. In this study, seven new co-polymers were synthesized under mild reaction conditions in bulk (without solvent) by chemoenzymatic approach using Candida antarctica lipase (Novozyme 435) and molecular sieves, subsequently these polymers were treated with different long chain bromoalkanes and acid chlorides for attachment of the lipophilic moieties to the backbone polymer via an ether or an ester linkage, respectively in order to make them amphiphilic. These synthesized nano-particles demonstrated high drug loading capacity and have the potential to encapsulate hydrophobic drugs.",

keywords = "EGylated amphiphilic copolymers, curcumin encapsulation, drug delivery, nanocarriers",

author = "Vijayendra Kumar and Bhavna Gupta and Gaurav Kumar and Pandey, {Mukesh K.} and Eric Aiazian and Parmar, {Virinder S.} and Jayant Kumar and Watterson, {Arthur C.}",

note = "Funding Information: The authors gratefully acknowledge the financial support from the Genus Biotech Corporation, Delaware, USA; University of Massachusetts, Lowell, MA and the University of Delhi, Delhi, India.",

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doi = "10.1080/10601325.2010.518549",

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T2 - Synthesis, characterization and curcumin encapsulation

AU - Kumar, Vijayendra

AU - Gupta, Bhavna

AU - Kumar, Gaurav

AU - Pandey, Mukesh K.

AU - Aiazian, Eric

AU - Parmar, Virinder S.

AU - Kumar, Jayant

AU - Watterson, Arthur C.

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PY - 2010/12

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N2 - Amphiphilic polymers can self assemble into micellar nano-particles and can be effectively used as nano carriers for drug delivery. A number of macromolecular delivery systems are under investigation to improve the efficacy of prospective drugs. In this study, seven new co-polymers were synthesized under mild reaction conditions in bulk (without solvent) by chemoenzymatic approach using Candida antarctica lipase (Novozyme 435) and molecular sieves, subsequently these polymers were treated with different long chain bromoalkanes and acid chlorides for attachment of the lipophilic moieties to the backbone polymer via an ether or an ester linkage, respectively in order to make them amphiphilic. These synthesized nano-particles demonstrated high drug loading capacity and have the potential to encapsulate hydrophobic drugs.

AB - Amphiphilic polymers can self assemble into micellar nano-particles and can be effectively used as nano carriers for drug delivery. A number of macromolecular delivery systems are under investigation to improve the efficacy of prospective drugs. In this study, seven new co-polymers were synthesized under mild reaction conditions in bulk (without solvent) by chemoenzymatic approach using Candida antarctica lipase (Novozyme 435) and molecular sieves, subsequently these polymers were treated with different long chain bromoalkanes and acid chlorides for attachment of the lipophilic moieties to the backbone polymer via an ether or an ester linkage, respectively in order to make them amphiphilic. These synthesized nano-particles demonstrated high drug loading capacity and have the potential to encapsulate hydrophobic drugs.

KW - EGylated amphiphilic copolymers

KW - curcumin encapsulation

KW - drug delivery

KW - nanocarriers

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Novel PEGylated amphiphilic copolymers as nanocarriers for drug delivery: Synthesis, characterization and curcumin encapsulation

Abstract

Keywords

ASJC Scopus subject areas

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