TY - JOUR
T1 - Noninvasive measurement of gastric accommodation in patients with idiopathic nonulcer dyspepsia
AU - Kim, Doe Young
AU - Delgado-Aros, Silvia
AU - Camilleri, Michael
AU - Samsom, Melvin
AU - Murray, Joseph A.
AU - O'Connor, Michael K.
AU - Brinkmann, Benjamin H.
AU - Stephens, Debra A.
AU - Lighvani, Sebastian S.
AU - Burton, Duane D.
N1 - Funding Information:
This study was supported in part by grants R01 DK-54681-03 (MC) and K24 DK-02638-03 (MC) and by General Clinical Research Center grant RR00585 from the National Institutes of Health. Dr. Samsom is a fellow of the Royal Netherlands Academy of Arts and Sciences. We thank our colleagues in the Motility Interest Group at Mayo Clinic for referring patients, Mrs. Cindy Stanislav for typing and preparing this manuscript, and Timothy J. Hardyman for technical assistance.
PY - 2001
Y1 - 2001
N2 - OBJECTIVES: Postprandial symptoms are associated with impaired postprandial gastric accommodation. The aims of this study were to apply a noninvasive method to measure accommodation of the entire stomach in healthy subjects and in patients with idiopathic dyspeptic symptoms, and to assess the frequency of abnormal gastric accommodation and emptying of solids in these patients. METHODS: In 20 healthy volunteers and 32 tertiary referral patients, we used i.v. 99mTc-single photon emission computed tomography (SPECT) to measure fasting and post-prandial gastric volumes; we expressed the volume response to feeding ("accommodation") as the change in gastric volume and the ratio of postprandial/fasting volumes. The stomach was identified in transaxial SPECT tomographic images using a semiautomated, intensity-based extraction algorithm. Whole gastric volumes were measured using AnalyzeAVW software. Gastric emptying in patients was measured by scintigraphy. We also assessed dyspeptic symptoms and the association with normal or reduced accommodation. RESULTS: SPECT imaging detects the postprandial change in gastric volume ("accommodation") in health and disease. Among healthy subjects (eight men, 12 women), the post-prandial/fasting gastric volume ratio was 4.9 ± 1.7 (mean ± SD; fifth through 95th percentiles 3-8, median 4.6). Thirteen (41%) patients with idiopathic nonulcer dyspepsia had reduced postprandial "accommodation." Gastric emptying was fast in four (13%), normal in 25 (78%), and slow in three (9%) patients. Both tests were normal in 50% of patients. Weight loss of >10 pounds tended to be more frequently observed in those with reduced "accommodation" (62% vs 32%, p = 0.09). CONCLUSIONS: SPECT imaging noninvasively measures fasting and postprandial gastric volumes in humans. Half the patients with idiopathic nonulcer dyspepsia had impaired gastric accommodation or emptying. Reduced gastric "accommodation" was observed in 41% of a group with idiopathic nonulcer dyspepsia. Abnormal gastric emptying is less frequent (22%).
AB - OBJECTIVES: Postprandial symptoms are associated with impaired postprandial gastric accommodation. The aims of this study were to apply a noninvasive method to measure accommodation of the entire stomach in healthy subjects and in patients with idiopathic dyspeptic symptoms, and to assess the frequency of abnormal gastric accommodation and emptying of solids in these patients. METHODS: In 20 healthy volunteers and 32 tertiary referral patients, we used i.v. 99mTc-single photon emission computed tomography (SPECT) to measure fasting and post-prandial gastric volumes; we expressed the volume response to feeding ("accommodation") as the change in gastric volume and the ratio of postprandial/fasting volumes. The stomach was identified in transaxial SPECT tomographic images using a semiautomated, intensity-based extraction algorithm. Whole gastric volumes were measured using AnalyzeAVW software. Gastric emptying in patients was measured by scintigraphy. We also assessed dyspeptic symptoms and the association with normal or reduced accommodation. RESULTS: SPECT imaging detects the postprandial change in gastric volume ("accommodation") in health and disease. Among healthy subjects (eight men, 12 women), the post-prandial/fasting gastric volume ratio was 4.9 ± 1.7 (mean ± SD; fifth through 95th percentiles 3-8, median 4.6). Thirteen (41%) patients with idiopathic nonulcer dyspepsia had reduced postprandial "accommodation." Gastric emptying was fast in four (13%), normal in 25 (78%), and slow in three (9%) patients. Both tests were normal in 50% of patients. Weight loss of >10 pounds tended to be more frequently observed in those with reduced "accommodation" (62% vs 32%, p = 0.09). CONCLUSIONS: SPECT imaging noninvasively measures fasting and postprandial gastric volumes in humans. Half the patients with idiopathic nonulcer dyspepsia had impaired gastric accommodation or emptying. Reduced gastric "accommodation" was observed in 41% of a group with idiopathic nonulcer dyspepsia. Abnormal gastric emptying is less frequent (22%).
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U2 - 10.1016/S0002-9270(01)03826-6
DO - 10.1016/S0002-9270(01)03826-6
M3 - Article
C2 - 11721755
AN - SCOPUS:0035184878
SN - 0002-9270
VL - 96
SP - 3099
EP - 3105
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 11
ER -