Non-invasive model-based estimation of the sinus node dynamic properties from spontaneous cardiovascular variability series

Alberto Porta, N. Montano, M. Pagani, A. Malliani, G. Baselli, Virend Somers, P. van de Borne

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A non-invasive model-based approach to the estimation of sinus node dynamic properties is proposed. The model exploits the spontaneous beat-to-beat variability of heart period and systolic arterial pressure and the sampled respiration, thus surrogating the information from direct measures of neural activity. The residual heart period variability not related to baroreflex, to direct effects of respiration and to low frequency influences independent of baroreflex, is interpreted as the effect of the dynamic properties of the sinus node and modelled as a regression of the RR interval over its previous value. Therefore the sinus node transfer function is modelled by means of a filter with a real pole z = μ (and a zero in the origin). It was found that: first, in young healthy subjects the nodal tissue responded as a low-pass filter with μ = 0.76 ± 0.12 (mean ± SD); secondly, ageing did not significantly modify either its shape or gain at 0 Hz; thirdly, in heart transplant recipients, the dynamic transduction properties were lost (all-pass filter, μ = 0.06 ± 0.16, p < 0.001); fourthly, low-dose atropine left the sinus node dynamic properties unmodified; fifthly, high-dose atropine affected the dynamic transduction properties by increasing the gain at 0 Hz and rendering steeper its roll-off (the percent increase of μ with respect to baseline was 18.3 ± 22.3, p < 0.05).

Original languageEnglish (US)
Pages (from-to)52-61
Number of pages10
JournalMedical and Biological Engineering and Computing
Volume41
Issue number1
DOIs
StatePublished - Jan 2003

Fingerprint

Sinoatrial Node
Baroreflex
Atropine
Respiration
All-pass filters
Transplants
Low pass filters
Healthy Volunteers
Arterial Pressure
Transfer functions
Blood Pressure
Poles
Aging of materials
Tissue

Keywords

  • Atropine
  • Cardiovascular control
  • Cardiovascular variability
  • Heart transplantation
  • Parametric multivariate model
  • Sinus node transfer function

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Non-invasive model-based estimation of the sinus node dynamic properties from spontaneous cardiovascular variability series. / Porta, Alberto; Montano, N.; Pagani, M.; Malliani, A.; Baselli, G.; Somers, Virend; van de Borne, P.

In: Medical and Biological Engineering and Computing, Vol. 41, No. 1, 01.2003, p. 52-61.

Research output: Contribution to journalArticle

Porta, Alberto ; Montano, N. ; Pagani, M. ; Malliani, A. ; Baselli, G. ; Somers, Virend ; van de Borne, P. / Non-invasive model-based estimation of the sinus node dynamic properties from spontaneous cardiovascular variability series. In: Medical and Biological Engineering and Computing. 2003 ; Vol. 41, No. 1. pp. 52-61.
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