Non-invasive isometric force measurement of plantar flexors in rats

Aditya Chawla, Robert J. Spinner, Michael Torres Lizardi, Michael J Yaszemski, Anthony John Windebank, Huan D Wang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

INTRODUCTION: Isometric muscle force measurement is a sensitive marker for motor function recovery in rat nerve repair models. Current methods of eliciting maximal isometric force with nerve stimulation cannot provide longitudinal data.

METHODS: We developed a novel method for measuring isometric muscle force with a device designed to allow minimally invasive nerve stimulation and measurement of plantar flexion force. This indirectly elicited muscle force was compared with muscle force elicited by direct muscle stimulation in 3 surgical models.

RESULTS: The force measured after sciatic nerve transection and repair followed a parabolic trend. There was a postinjury decrease in force that continued until postoperative day 42, after which the force increased with time, indicating muscle reinnervation.

CONCLUSIONS: This approach can track longitudinal changes in force in the most common animal model for studies of clinically relevant problems in the peripheral nerve field.

Original languageEnglish (US)
Pages (from-to)812-821
Number of pages10
JournalMuscle & nerve
Volume50
Issue number5
DOIs
StatePublished - Nov 1 2014

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Muscles
Anatomic Models
Recovery of Function
Sciatic Nerve
Peripheral Nerves
Animal Models
Equipment and Supplies

Keywords

  • functional evaluation
  • isometric force
  • nerve injury
  • noninvasive
  • rat

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Non-invasive isometric force measurement of plantar flexors in rats. / Chawla, Aditya; Spinner, Robert J.; Torres Lizardi, Michael; Yaszemski, Michael J; Windebank, Anthony John; Wang, Huan D.

In: Muscle & nerve, Vol. 50, No. 5, 01.11.2014, p. 812-821.

Research output: Contribution to journalArticle

Chawla, Aditya ; Spinner, Robert J. ; Torres Lizardi, Michael ; Yaszemski, Michael J ; Windebank, Anthony John ; Wang, Huan D. / Non-invasive isometric force measurement of plantar flexors in rats. In: Muscle & nerve. 2014 ; Vol. 50, No. 5. pp. 812-821.
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