Non-invasive coronary angiography with high resolution multidetector-row computed tomography

Results in 102 patients

Andreas F. Kopp, S. Schroeder, A. Kuettner, A. Baumbach, C. Georg, Ronald S Kuzo, M. Heuschmid, B. Ohnesorge, K. R. Karsch, C. D. Claussen

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Aims: A new generation of multidetector-row CT (MDCT) scanners allows complete coronary coverage using retrospective ECG gating and 1 mm. slices. The purpose of this study was to investigate the potential of high resolution MDCT angiography with retrospective gating for detection of coronary artery stenoses. Methods and Results: A total of 102 patients underwent both conventional and MDCT coronary angiography. After intravenous injection of a non-ionic contrast medium the entire heart was scanned within a single breath hold using 1 mm. slices. All MDCT data sets were reconstructed with retrospective gating at 20% to 80% in increments of 10% relative to the cardiac cycle. Two blinded independent reviewers analysed image quality for segments 1-4 (right coronary artery), 5-8 (left main, left anterior descending), and 11, 12 (left circumflex). These segments were evaluated for the presence or absence of significant (≥50%) stenoses. The results were compared with those of invasive coronary angiography in a blinded fashion. Overall sensitivity for the detection of significant stenoses (≥50%) were 0.86 (reader 1) and 0.93 (reader 2), specificity 0.96 (reader 1) and 0.97 (reader 2), negative predictive value 0.98 (reader 1) and 0.99 (reader 2). Conclusions: High resolution MDCT angiography with retrospective gating permits the non-invasive detection of coronary artery stenoses with high accuracy if image quality is optimized for each of the three major coronary arteries.

Original languageEnglish (US)
Pages (from-to)1714-1725
Number of pages12
JournalEuropean Heart Journal
Volume23
Issue number21
DOIs
StatePublished - Nov 2002

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Multidetector Computed Tomography
Coronary Angiography
Coronary Stenosis
Coronary Vessels
Pathologic Constriction
Intravenous Injections
Contrast Media
Electrocardiography
Computed Tomography Angiography

Keywords

  • Computed tomography angiography (CTA)
  • Coronary artery disease (CAD)
  • Image reconstruction
  • Multidetector-row computed tomography (MDCT)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Non-invasive coronary angiography with high resolution multidetector-row computed tomography : Results in 102 patients. / Kopp, Andreas F.; Schroeder, S.; Kuettner, A.; Baumbach, A.; Georg, C.; Kuzo, Ronald S; Heuschmid, M.; Ohnesorge, B.; Karsch, K. R.; Claussen, C. D.

In: European Heart Journal, Vol. 23, No. 21, 11.2002, p. 1714-1725.

Research output: Contribution to journalArticle

Kopp, AF, Schroeder, S, Kuettner, A, Baumbach, A, Georg, C, Kuzo, RS, Heuschmid, M, Ohnesorge, B, Karsch, KR & Claussen, CD 2002, 'Non-invasive coronary angiography with high resolution multidetector-row computed tomography: Results in 102 patients', European Heart Journal, vol. 23, no. 21, pp. 1714-1725. https://doi.org/10.1016/S0195-668X(02)93264-1
Kopp, Andreas F. ; Schroeder, S. ; Kuettner, A. ; Baumbach, A. ; Georg, C. ; Kuzo, Ronald S ; Heuschmid, M. ; Ohnesorge, B. ; Karsch, K. R. ; Claussen, C. D. / Non-invasive coronary angiography with high resolution multidetector-row computed tomography : Results in 102 patients. In: European Heart Journal. 2002 ; Vol. 23, No. 21. pp. 1714-1725.
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AU - Georg, C.

AU - Kuzo, Ronald S

AU - Heuschmid, M.

AU - Ohnesorge, B.

AU - Karsch, K. R.

AU - Claussen, C. D.

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AB - Aims: A new generation of multidetector-row CT (MDCT) scanners allows complete coronary coverage using retrospective ECG gating and 1 mm. slices. The purpose of this study was to investigate the potential of high resolution MDCT angiography with retrospective gating for detection of coronary artery stenoses. Methods and Results: A total of 102 patients underwent both conventional and MDCT coronary angiography. After intravenous injection of a non-ionic contrast medium the entire heart was scanned within a single breath hold using 1 mm. slices. All MDCT data sets were reconstructed with retrospective gating at 20% to 80% in increments of 10% relative to the cardiac cycle. Two blinded independent reviewers analysed image quality for segments 1-4 (right coronary artery), 5-8 (left main, left anterior descending), and 11, 12 (left circumflex). These segments were evaluated for the presence or absence of significant (≥50%) stenoses. The results were compared with those of invasive coronary angiography in a blinded fashion. Overall sensitivity for the detection of significant stenoses (≥50%) were 0.86 (reader 1) and 0.93 (reader 2), specificity 0.96 (reader 1) and 0.97 (reader 2), negative predictive value 0.98 (reader 1) and 0.99 (reader 2). Conclusions: High resolution MDCT angiography with retrospective gating permits the non-invasive detection of coronary artery stenoses with high accuracy if image quality is optimized for each of the three major coronary arteries.

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