Nodular Glomerulosclerosis

Renal Lesions in Chronic Smokers Mimic Chronic Thrombotic Microangiopathy and Hypertensive Lesions

Kelly V. Liang, Eddie L. Greene, Liem Som Oei, Matthew Lewin, Donna Lager, Sanjeev M Sethi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cigarette smoking is associated with vascular lesions and chronic renal failure. In this report, we describe clinical and kidney biopsy findings for a 66-year-old woman with a history of long-term heavy cigarette smoking who developed proteinuria and decreasing renal function. This study also describes clinical and kidney biopsy findings for 9 patients with a history of smoking. None of these patients had hypertension, diabetes mellitus, or other risk factors that might result in vascular injury. Renal biopsy specimens showed a range of long-term changes with varying degrees of focal segmental or focal global glomerulosclerosis, nodular glomerulosclerosis, ischemic glomeruli, interstitial fibrosis and tubular atrophy, and mild to moderate arterial sclerosis and arteriolar hyalinosis. Electron microscopy often showed glomerular capillary wall thickening caused by subendothelial expansion by cellular elements and new basement formation resulting in segments of double contours. These changes indicate endothelial injury and glomerular capillary wall remodeling; the lesions mimic those seen in patients with chronic hypertension and chronic or healed thrombotic microangiopathies.

Original languageEnglish (US)
Pages (from-to)552-559
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume49
Issue number4
DOIs
StatePublished - Apr 2007

Fingerprint

Thrombotic Microangiopathies
Diabetic Nephropathies
Kidney
Smoking
Biopsy
Hypertension
Focal Segmental Glomerulosclerosis
Vascular System Injuries
Sclerosis
Proteinuria
Chronic Kidney Failure
Atrophy
Blood Vessels
Electron Microscopy
Diabetes Mellitus
Fibrosis
tebufenozide
Wounds and Injuries

Keywords

  • chronic thrombotic microangiopathy
  • focal segmental glomerulosclerosis
  • hypertension
  • Kidney
  • nodular glomerulosclerosis
  • smoking

ASJC Scopus subject areas

  • Nephrology

Cite this

Nodular Glomerulosclerosis : Renal Lesions in Chronic Smokers Mimic Chronic Thrombotic Microangiopathy and Hypertensive Lesions. / Liang, Kelly V.; Greene, Eddie L.; Oei, Liem Som; Lewin, Matthew; Lager, Donna; Sethi, Sanjeev M.

In: American Journal of Kidney Diseases, Vol. 49, No. 4, 04.2007, p. 552-559.

Research output: Contribution to journalArticle

Liang, Kelly V. ; Greene, Eddie L. ; Oei, Liem Som ; Lewin, Matthew ; Lager, Donna ; Sethi, Sanjeev M. / Nodular Glomerulosclerosis : Renal Lesions in Chronic Smokers Mimic Chronic Thrombotic Microangiopathy and Hypertensive Lesions. In: American Journal of Kidney Diseases. 2007 ; Vol. 49, No. 4. pp. 552-559.
@article{5cc988f6043042a6b77f1a261ebc7af9,
title = "Nodular Glomerulosclerosis: Renal Lesions in Chronic Smokers Mimic Chronic Thrombotic Microangiopathy and Hypertensive Lesions",
abstract = "Cigarette smoking is associated with vascular lesions and chronic renal failure. In this report, we describe clinical and kidney biopsy findings for a 66-year-old woman with a history of long-term heavy cigarette smoking who developed proteinuria and decreasing renal function. This study also describes clinical and kidney biopsy findings for 9 patients with a history of smoking. None of these patients had hypertension, diabetes mellitus, or other risk factors that might result in vascular injury. Renal biopsy specimens showed a range of long-term changes with varying degrees of focal segmental or focal global glomerulosclerosis, nodular glomerulosclerosis, ischemic glomeruli, interstitial fibrosis and tubular atrophy, and mild to moderate arterial sclerosis and arteriolar hyalinosis. Electron microscopy often showed glomerular capillary wall thickening caused by subendothelial expansion by cellular elements and new basement formation resulting in segments of double contours. These changes indicate endothelial injury and glomerular capillary wall remodeling; the lesions mimic those seen in patients with chronic hypertension and chronic or healed thrombotic microangiopathies.",
keywords = "chronic thrombotic microangiopathy, focal segmental glomerulosclerosis, hypertension, Kidney, nodular glomerulosclerosis, smoking",
author = "Liang, {Kelly V.} and Greene, {Eddie L.} and Oei, {Liem Som} and Matthew Lewin and Donna Lager and Sethi, {Sanjeev M}",
year = "2007",
month = "4",
doi = "10.1053/j.ajkd.2007.01.014",
language = "English (US)",
volume = "49",
pages = "552--559",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Nodular Glomerulosclerosis

T2 - Renal Lesions in Chronic Smokers Mimic Chronic Thrombotic Microangiopathy and Hypertensive Lesions

AU - Liang, Kelly V.

AU - Greene, Eddie L.

AU - Oei, Liem Som

AU - Lewin, Matthew

AU - Lager, Donna

AU - Sethi, Sanjeev M

PY - 2007/4

Y1 - 2007/4

N2 - Cigarette smoking is associated with vascular lesions and chronic renal failure. In this report, we describe clinical and kidney biopsy findings for a 66-year-old woman with a history of long-term heavy cigarette smoking who developed proteinuria and decreasing renal function. This study also describes clinical and kidney biopsy findings for 9 patients with a history of smoking. None of these patients had hypertension, diabetes mellitus, or other risk factors that might result in vascular injury. Renal biopsy specimens showed a range of long-term changes with varying degrees of focal segmental or focal global glomerulosclerosis, nodular glomerulosclerosis, ischemic glomeruli, interstitial fibrosis and tubular atrophy, and mild to moderate arterial sclerosis and arteriolar hyalinosis. Electron microscopy often showed glomerular capillary wall thickening caused by subendothelial expansion by cellular elements and new basement formation resulting in segments of double contours. These changes indicate endothelial injury and glomerular capillary wall remodeling; the lesions mimic those seen in patients with chronic hypertension and chronic or healed thrombotic microangiopathies.

AB - Cigarette smoking is associated with vascular lesions and chronic renal failure. In this report, we describe clinical and kidney biopsy findings for a 66-year-old woman with a history of long-term heavy cigarette smoking who developed proteinuria and decreasing renal function. This study also describes clinical and kidney biopsy findings for 9 patients with a history of smoking. None of these patients had hypertension, diabetes mellitus, or other risk factors that might result in vascular injury. Renal biopsy specimens showed a range of long-term changes with varying degrees of focal segmental or focal global glomerulosclerosis, nodular glomerulosclerosis, ischemic glomeruli, interstitial fibrosis and tubular atrophy, and mild to moderate arterial sclerosis and arteriolar hyalinosis. Electron microscopy often showed glomerular capillary wall thickening caused by subendothelial expansion by cellular elements and new basement formation resulting in segments of double contours. These changes indicate endothelial injury and glomerular capillary wall remodeling; the lesions mimic those seen in patients with chronic hypertension and chronic or healed thrombotic microangiopathies.

KW - chronic thrombotic microangiopathy

KW - focal segmental glomerulosclerosis

KW - hypertension

KW - Kidney

KW - nodular glomerulosclerosis

KW - smoking

UR - http://www.scopus.com/inward/record.url?scp=33947313520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947313520&partnerID=8YFLogxK

U2 - 10.1053/j.ajkd.2007.01.014

DO - 10.1053/j.ajkd.2007.01.014

M3 - Article

VL - 49

SP - 552

EP - 559

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 4

ER -