No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease

J. Eric Ahlskog, Ryan J. Uitti, Phillip A. Low, Gertrude M. Tyce, Kim K. Nickander, Ronald C. Petersen, Emre Kokmen

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Oxidant stress secondary to dopamine metabolism has been proposed as a pathogenic factor in the development of Parkinson's disease. Biochemical abnormalities extending beyond the central nervous system have been identified in patients with this condition. Previous investigators have found abnormally elevated concentrations of the lipid peroxidation product, malondialdehyde, in the plasma and serum of patients with Parkinson's disease. We attempted to replicate these findings but controlled for other factors that could influence malondialdehyde levels. We detected no significant elevations in mean serum malondialdehyde concentrations in either levodopatreated or untreated patients with Parkinson's disease, compared to normal controls; similarly, no elevation was found in a group of patients with dementia of Alzheimer's type. On the other hand, a group of subjects with diabetes mellitus but no neurodegenerative disease had significantly elevated mean serum malondialdehyde levels, consistent with previous studies of diabetic patients. Autoxidation is one of the two major routes by which dopamine and dopa metabolism may generate oxygen free radicals. We analyzed the autoxidation product of dopa, 5‐S‐cysteinyl‐dopa, in the plasma of these same groups of patients with neurodegenerative disease and normal controls; no significant differences were identified. Serum concentrations of two other antioxidant substances, α‐tocopherol and uric acid, were also statistically similar in these groups. In conclusion, analysis of several blood products relevant to oxidant stress, including malondialdehyde, 5‐S‐cysteinyl‐dopa, α‐tocophero, and uric acid, failed to distinguish patients with Parkinson's disease or dementia of Alzheimer's type from controls.

Original languageEnglish (US)
Pages (from-to)566-573
Number of pages8
JournalMovement Disorders
Volume10
Issue number5
DOIs
StatePublished - Sep 1995

Keywords

  • 5‐S‐Cysteinyl‐dopa
  • Alzheimer's disease
  • Diabetes mellitus
  • Malondialdehyde
  • Oxidant stress
  • Parkinson's disease
  • α‐Tocopherol

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease'. Together they form a unique fingerprint.

Cite this