Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerization

Medicine & Life Sciences

• Sickle Cell Anemia 100%
• Polymerization 94%
• Tyrosine 84%
• Actins 77%
• Nitric Oxide 74%
• Kidney 21%
• Liver 20%
• Hemoglobins 16%
• Reactive Oxygen Species 16%
• Proteins 14%
• 3-nitrotyrosine 13%
• Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry 12%
• Blood Vessels 11%
• Gas Chromatography-Mass Spectrometry 11%
• Tandem Mass Spectrometry 11%
• In Situ Nick-End Labeling 10%
• Nitric Oxide Synthase Type II 10%
• Oxidants 10%
• Point Mutation 9%
• Immunoprecipitation 9%
• Reperfusion Injury 9%
• Confocal Microscopy 9%
• Digestion 9%
• Mass Spectrometry 9%
• Blood Proteins 9%
• Gels 8%
• Western Blotting 6%
• Staining and Labeling 6%
• Apoptosis 6%

Chemical Compounds

• Tyrosine 83%
• Polymerization Reaction 54%
• Protein 37%
• Reactive Oxygen Metabolite 34%
• Hemoglobin 34%
• 3-Nitrotyrosine 28%
• Apoptotic 21%
• Tyrosine Residue 21%
• Matrix Assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) 20%
• Confocal Microscopy 20%
• Electrospray Ionization 16%
• Mutation 15%
• Tandem Mass Spectrometry 15%
• Gas Chromatography Mass Spectrometry (GCMS) 13%
• Plasma 11%