Nitric oxide and the pulmonary artery smooth muscle cell

Amy C Degnim, D. K. Nakayama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nitric oxide (NO) is produced by the enzyme nitric oxide synthase (NOS), which exists in different isoforms in various tissues. The inducible NOS (iNOS) isoform of the enzyme is expressed in vascular smooth muscle in response to lipopolysaccharide and inflammatory mediators. When this expression of iNOS occurs in the lung, the NO produced may play a role in the inflammatory process of acute lung injury. This article reviews the research that characterizes iNOS in rat pulmonary artery smooth muscle and discusses current investigation into the role of NO in sepsis and injury.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalSeminars in Pediatric Surgery
Volume5
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Pulmonary Artery
Smooth Muscle Myocytes
Nitric Oxide
Protein Isoforms
Acute Lung Injury
Nitric Oxide Synthase Type II
Enzymes
Vascular Smooth Muscle
Nitric Oxide Synthase
Smooth Muscle
Lipopolysaccharides
Sepsis
Lung
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nitric oxide and the pulmonary artery smooth muscle cell. / Degnim, Amy C; Nakayama, D. K.

In: Seminars in Pediatric Surgery, Vol. 5, No. 3, 1996, p. 160-164.

Research output: Contribution to journalArticle

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