Newer aspects of carnitine metabolism in uremia

Vincenzo Savica; Menotti Calvani; Paola Benatti; Domenico Santoro; Paolo Monardo; Agostino Mallamace; Rodolfo Savica; Guido Bellinghieri

doi:10.1016/j.semnephrol.2005.06.010

Newer aspects of carnitine metabolism in uremia

Vincenzo Savica, Menotti Calvani, Paola Benatti, Domenico Santoro, Paolo Monardo, Agostino Mallamace, Rodolfo Savica, Guido Bellinghieri

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypotensive episodes, improves ejection fraction, and decreases hospitalization.

Original language	English (US)
Pages (from-to)	52-55
Number of pages	4
Journal	Seminars in nephrology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.semnephrol.2005.06.010
State	Published - Jan 2006

Keywords

Carnitine
Carnitine acyltransferase
Carnitine deficiency
Hemodialysis
Mitochondria

ASJC Scopus subject areas

Nephrology

Access to Document

10.1016/j.semnephrol.2005.06.010

Cite this

@article{f449f561255e485fb08124a25c72e5cd,

title = "Newer aspects of carnitine metabolism in uremia",

abstract = "New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypotensive episodes, improves ejection fraction, and decreases hospitalization.",

keywords = "Carnitine, Carnitine acyltransferase, Carnitine deficiency, Hemodialysis, Mitochondria",

author = "Vincenzo Savica and Menotti Calvani and Paola Benatti and Domenico Santoro and Paolo Monardo and Agostino Mallamace and Rodolfo Savica and Guido Bellinghieri",

year = "2006",

month = jan,

doi = "10.1016/j.semnephrol.2005.06.010",

language = "English (US)",

volume = "26",

pages = "52--55",

journal = "Seminars in nephrology",

issn = "0270-9295",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Newer aspects of carnitine metabolism in uremia

AU - Savica, Vincenzo

AU - Calvani, Menotti

AU - Benatti, Paola

AU - Santoro, Domenico

AU - Monardo, Paolo

AU - Mallamace, Agostino

AU - Savica, Rodolfo

AU - Bellinghieri, Guido

PY - 2006/1

Y1 - 2006/1

N2 - New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypotensive episodes, improves ejection fraction, and decreases hospitalization.

AB - New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypotensive episodes, improves ejection fraction, and decreases hospitalization.

KW - Carnitine

KW - Carnitine acyltransferase

KW - Carnitine deficiency

KW - Hemodialysis

KW - Mitochondria

UR - http://www.scopus.com/inward/record.url?scp=30444440888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30444440888&partnerID=8YFLogxK

U2 - 10.1016/j.semnephrol.2005.06.010

DO - 10.1016/j.semnephrol.2005.06.010

M3 - Article

C2 - 16412827

AN - SCOPUS:30444440888

SN - 0270-9295

VL - 26

SP - 52

EP - 55

JO - Seminars in nephrology

JF - Seminars in nephrology

IS - 1

ER -

Newer aspects of carnitine metabolism in uremia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this