Newer aspects of carnitine metabolism in uremia

Vincenzo Savica, Menotti Calvani, Paola Benatti, Domenico Santoro, Paolo Monardo, Agostino Mallamace, Rodolfo Savica, Guido Bellinghieri

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

New knowledge on the physiologic role of L-carnitine and on the rationale of its use in patients on maintenance hemodialysis is provided. In particular, carnitine normalizes plasma and muscle carnitine levels and modifies both enzymatic pattern of muscle and morphology of single fibers, improving exercise tolerance. In addition, carnitine reduces erythropoietin requirements, the number of hypotensive episodes, improves ejection fraction, and decreases hospitalization.

Original languageEnglish (US)
Pages (from-to)52-55
Number of pages4
JournalSeminars in nephrology
Volume26
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Carnitine
  • Carnitine acyltransferase
  • Carnitine deficiency
  • Hemodialysis
  • Mitochondria

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Savica, V., Calvani, M., Benatti, P., Santoro, D., Monardo, P., Mallamace, A., Savica, R., & Bellinghieri, G. (2006). Newer aspects of carnitine metabolism in uremia. Seminars in nephrology, 26(1), 52-55. https://doi.org/10.1016/j.semnephrol.2005.06.010