New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

Thiago M. De Assuncao, Gwen Lomberk, Sheng Cao, Usman Yaqoob, Angela Mathison, Douglas A. Simonetto, Robert C. Huebert, Raul A. Urrutia, Vijay H. Shah

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.

Original languageEnglish (US)
Pages (from-to)15798-15809
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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