New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

Thiago M. De Assuncao; Gwen Lomberk; Sheng Cao; Usman Yaqoob; Angela Mathison; Douglas A. Simonetto; Robert C. Huebert; Raul A. Urrutia; Vijay H. Shah

doi:10.1074/jbc.M113.544346

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

Thiago M. De Assuncao, Gwen Lomberk, Sheng Cao, Usman Yaqoob, Angela Mathison, Douglas A. Simonetto, Robert C. Huebert, Raul A. Urrutia, Vijay H. Shah

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.

Original language	English (US)
Pages (from-to)	15798-15809
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.544346
State	Published - May 30 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids",

abstract = "Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.",

author = "{De Assuncao}, {Thiago M.} and Gwen Lomberk and Sheng Cao and Usman Yaqoob and Angela Mathison and Simonetto, {Douglas A.} and Huebert, {Robert C.} and Urrutia, {Raul A.} and Shah, {Vijay H.}",

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AU - De Assuncao, Thiago M.

AU - Lomberk, Gwen

AU - Cao, Sheng

AU - Yaqoob, Usman

AU - Mathison, Angela

AU - Simonetto, Douglas A.

AU - Huebert, Robert C.

AU - Urrutia, Raul A.

AU - Shah, Vijay H.

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.

AB - Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.

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New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

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