New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

Thiago M. De Assuncao, Gwen Lomberk, Sheng Cao, Usman Yaqoob, Angela Mathison, Douglas Simonetto, Robert C Huebert, Raul A. Urrutia, Vijay Shah

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: KLF14 has elicited attention as a master regulator of lipid metabolism. Results: KLF14 regulates chromatin remodeling on sphingosine kinase 1 gene leading to its activation and sphingosine-1-phosphate production. Conclusion: KLF14 acts as a transcriptional activator for the generation of lipid signaling molecules. Significance: This new knowledge extends the functions assigned to KLF14 and contributes to understanding its role in human diseases.

Original languageEnglish (US)
Pages (from-to)15798-15809
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

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Kruppel-Like Transcription Factors
Chromatin Assembly and Disassembly
Lipid Metabolism
Chromatin
Genes
Chemical activation
Lipids
Molecules
sphingosine 1-phosphate
sphingosine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. / De Assuncao, Thiago M.; Lomberk, Gwen; Cao, Sheng; Yaqoob, Usman; Mathison, Angela; Simonetto, Douglas; Huebert, Robert C; Urrutia, Raul A.; Shah, Vijay.

In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15798-15809.

Research output: Contribution to journalArticle

De Assuncao, Thiago M. ; Lomberk, Gwen ; Cao, Sheng ; Yaqoob, Usman ; Mathison, Angela ; Simonetto, Douglas ; Huebert, Robert C ; Urrutia, Raul A. ; Shah, Vijay. / New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 22. pp. 15798-15809.
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