TY - JOUR
T1 - New features of disease after diagnosis in 6 forms of systemic vasculitis
AU - Grayson, Peter C.
AU - Cuthbertson, David
AU - Carette, Simon
AU - Hoffman, Gary S.
AU - Khalidi, Nader A.
AU - Koening, Curry L.
AU - Langford, Carol A.
AU - Maksimowicz-McKinnon, Kathleen
AU - Monach, Paul A.
AU - Seo, Philip
AU - Specks, Ulrich
AU - Ytterberg, Steven R.
AU - Merkel, Peter A.
PY - 2013/11
Y1 - 2013/11
N2 - Objective. To quantify the occurrence of features of vasculitis that initially present after diagnosis in 6 types of primary vasculitis. Methods. Standardized collection of data on 95 disease manifestations in 6 vasculitides, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (Churg-Strauss; EGPA), polyarteritis nodosa (PAN), giant cell arteritis (GCA), and Takayasu arteritis (TAK), was obtained within a set of multicenter longitudinal, observational cohorts. For each form of vasculitis, the frequency of disease-specific manifestations at diagnosis was compared to the cumulative frequency of each manifestation. The percentage of patients who initially developed severe manifestations after diagnosis, defined as organ- or life-threatening in the small and medium vessel vasculitides (GPA, MPA, EGPA, PAN) and as ischemic/vascular in the large vessel vasculitides (GCA, TAK), was reported. Results. Out of 838 patients with vasculitis, 490 (59%) experienced ≥ 1 new disease manifestation after diagnosis. On average, patients with vasculitis experienced 1.3 new manifestations after diagnosis (GPA = 1.9, MPA = 1.2, EGPA = 1.5, PAN = 1.2, GCA = 0.7, and TAK = 1.0). New severe manifestations occurred after diagnosis in 224 (27%) out of 838 patients (GPA = 26%, MPA = 19%, EGPA = 21%, PAN = 23%, GCA = 24%, and TAK = 44%). Timing of onset of new manifestations was not significantly associated with disease duration. Conclusion. A majority of patients with vasculitis develop new disease features after diagnosis, including a substantial number of new, severe manifestations. Ongoing assessment of patients with established vasculitis should remain broad in scope. The Journal of Rheumatology
AB - Objective. To quantify the occurrence of features of vasculitis that initially present after diagnosis in 6 types of primary vasculitis. Methods. Standardized collection of data on 95 disease manifestations in 6 vasculitides, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (Churg-Strauss; EGPA), polyarteritis nodosa (PAN), giant cell arteritis (GCA), and Takayasu arteritis (TAK), was obtained within a set of multicenter longitudinal, observational cohorts. For each form of vasculitis, the frequency of disease-specific manifestations at diagnosis was compared to the cumulative frequency of each manifestation. The percentage of patients who initially developed severe manifestations after diagnosis, defined as organ- or life-threatening in the small and medium vessel vasculitides (GPA, MPA, EGPA, PAN) and as ischemic/vascular in the large vessel vasculitides (GCA, TAK), was reported. Results. Out of 838 patients with vasculitis, 490 (59%) experienced ≥ 1 new disease manifestation after diagnosis. On average, patients with vasculitis experienced 1.3 new manifestations after diagnosis (GPA = 1.9, MPA = 1.2, EGPA = 1.5, PAN = 1.2, GCA = 0.7, and TAK = 1.0). New severe manifestations occurred after diagnosis in 224 (27%) out of 838 patients (GPA = 26%, MPA = 19%, EGPA = 21%, PAN = 23%, GCA = 24%, and TAK = 44%). Timing of onset of new manifestations was not significantly associated with disease duration. Conclusion. A majority of patients with vasculitis develop new disease features after diagnosis, including a substantial number of new, severe manifestations. Ongoing assessment of patients with established vasculitis should remain broad in scope. The Journal of Rheumatology
KW - EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS
KW - GIANT CELL ARTERITIS
KW - GRANULOMATOSIS WITH POLYANGIITIS
KW - MICROSCOPIC POLYANGIITIS
KW - POLYARTERITIS NODOSA
KW - TAKAYASU ARTERITIS
KW - VASCULITIS
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UR - http://www.scopus.com/inward/citedby.url?scp=84887497270&partnerID=8YFLogxK
U2 - 10.3899/jrheum.121473
DO - 10.3899/jrheum.121473
M3 - Article
C2 - 23908447
AN - SCOPUS:84887497270
SN - 0315-162X
VL - 40
SP - 1905
EP - 1912
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 11
ER -