Neurotrophins in lung health and disease

Ys Prakash, Michael A. Thompson, Lucas Meuchel, Christina M. Pabelick, Carlos B. Mantilla, Syed Zaidi, Richard J. Martin

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Neurotrophins (NTs) are a family of growth factors that are well-known in the nervous system. There is increasing recognition that NTs (nerve growth factor, brain-derived neurotrophic factor and NT3) and their receptors (high-affinity TrkA, TrkB and TrkC, and low-affinity p75NTR) are expressed in lung components including the nasal and bronchial epithelium, smooth muscle, nerves and immune cells. NT signaling may be important in normal lung development, developmental lung disease, allergy and inflammation (e.g., rhinitis, asthma), lung fibrosis and even lung cancer. In this review, we describe the current status of our understanding of NT signaling in the lung, with hopes of using aspects of the NT signaling pathway in the diagnosis and therapy of lung diseases.

Original languageEnglish (US)
Pages (from-to)395-411
Number of pages17
JournalExpert Review of Respiratory Medicine
Volume4
Issue number3
DOIs
StatePublished - Jun 1 2010

Keywords

  • Asthma
  • Bronchopulmonary dysplasia
  • Development
  • Fibrosis
  • Inflammation
  • Lung cancer
  • Neurotrophic factor
  • Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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