Neurotensin: Peptide for the next millennium

Beth M. Tyler-McMahon, Mona Boules, Elliott Richelson

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Neurotensin is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Try-Ile-Leu-OH) that was discovered by Carraway and Leeman in bovine hypothalami in the early 1970s. Since then this peptide has been the subject of a multitude of articles detailing discoveries related to its activity, receptors, localization, synthesis, and interactions with other systems. This review article does not intend to summarize again all the history of this fascinating peptide and its receptors, since this has been done quite well by others. The reader will be directed to these other reviews, where appropriate. Instead, this review attempts to provide a summary of current knowledge about neurotensin, why it is an important peptide to study, and where the field is heading. Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalRegulatory Peptides
Volume93
Issue number1-3
DOIs
StatePublished - Sep 25 2000

Fingerprint

Neurotensin
Peptides
Neurotransmitter Agents
Peptide Receptors
Hypothalamus
History

Keywords

  • Agonists
  • Antagonists
  • Antisense studies
  • Behavioral studies
  • Current knowledge
  • Neurotensin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Tyler-McMahon, B. M., Boules, M., & Richelson, E. (2000). Neurotensin: Peptide for the next millennium. Regulatory Peptides, 93(1-3), 125-136. https://doi.org/10.1016/S0167-0115(00)00183-X

Neurotensin : Peptide for the next millennium. / Tyler-McMahon, Beth M.; Boules, Mona; Richelson, Elliott.

In: Regulatory Peptides, Vol. 93, No. 1-3, 25.09.2000, p. 125-136.

Research output: Contribution to journalArticle

Tyler-McMahon, BM, Boules, M & Richelson, E 2000, 'Neurotensin: Peptide for the next millennium', Regulatory Peptides, vol. 93, no. 1-3, pp. 125-136. https://doi.org/10.1016/S0167-0115(00)00183-X
Tyler-McMahon BM, Boules M, Richelson E. Neurotensin: Peptide for the next millennium. Regulatory Peptides. 2000 Sep 25;93(1-3):125-136. https://doi.org/10.1016/S0167-0115(00)00183-X
Tyler-McMahon, Beth M. ; Boules, Mona ; Richelson, Elliott. / Neurotensin : Peptide for the next millennium. In: Regulatory Peptides. 2000 ; Vol. 93, No. 1-3. pp. 125-136.
@article{1ae5a647b4fb4c8293b58e2180efdeed,
title = "Neurotensin: Peptide for the next millennium",
abstract = "Neurotensin is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Try-Ile-Leu-OH) that was discovered by Carraway and Leeman in bovine hypothalami in the early 1970s. Since then this peptide has been the subject of a multitude of articles detailing discoveries related to its activity, receptors, localization, synthesis, and interactions with other systems. This review article does not intend to summarize again all the history of this fascinating peptide and its receptors, since this has been done quite well by others. The reader will be directed to these other reviews, where appropriate. Instead, this review attempts to provide a summary of current knowledge about neurotensin, why it is an important peptide to study, and where the field is heading. Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters. Copyright (C) 2000 Elsevier Science B.V.",
keywords = "Agonists, Antagonists, Antisense studies, Behavioral studies, Current knowledge, Neurotensin",
author = "Tyler-McMahon, {Beth M.} and Mona Boules and Elliott Richelson",
year = "2000",
month = "9",
day = "25",
doi = "10.1016/S0167-0115(00)00183-X",
language = "English (US)",
volume = "93",
pages = "125--136",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Neurotensin

T2 - Peptide for the next millennium

AU - Tyler-McMahon, Beth M.

AU - Boules, Mona

AU - Richelson, Elliott

PY - 2000/9/25

Y1 - 2000/9/25

N2 - Neurotensin is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Try-Ile-Leu-OH) that was discovered by Carraway and Leeman in bovine hypothalami in the early 1970s. Since then this peptide has been the subject of a multitude of articles detailing discoveries related to its activity, receptors, localization, synthesis, and interactions with other systems. This review article does not intend to summarize again all the history of this fascinating peptide and its receptors, since this has been done quite well by others. The reader will be directed to these other reviews, where appropriate. Instead, this review attempts to provide a summary of current knowledge about neurotensin, why it is an important peptide to study, and where the field is heading. Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters. Copyright (C) 2000 Elsevier Science B.V.

AB - Neurotensin is an endogenous tridecapeptide neurotransmitter (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Try-Ile-Leu-OH) that was discovered by Carraway and Leeman in bovine hypothalami in the early 1970s. Since then this peptide has been the subject of a multitude of articles detailing discoveries related to its activity, receptors, localization, synthesis, and interactions with other systems. This review article does not intend to summarize again all the history of this fascinating peptide and its receptors, since this has been done quite well by others. The reader will be directed to these other reviews, where appropriate. Instead, this review attempts to provide a summary of current knowledge about neurotensin, why it is an important peptide to study, and where the field is heading. Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters. Copyright (C) 2000 Elsevier Science B.V.

KW - Agonists

KW - Antagonists

KW - Antisense studies

KW - Behavioral studies

KW - Current knowledge

KW - Neurotensin

UR - http://www.scopus.com/inward/record.url?scp=0034715059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034715059&partnerID=8YFLogxK

U2 - 10.1016/S0167-0115(00)00183-X

DO - 10.1016/S0167-0115(00)00183-X

M3 - Article

C2 - 11033059

AN - SCOPUS:0034715059

VL - 93

SP - 125

EP - 136

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1-3

ER -