Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging

Mary Margaret Machulda, Emily S. Lundt, Sabrina M. Albertson, Walter K Kremers, Michelle M Mielke, David S Knopman, Mark W. Bondi, Ronald Carl Petersen

Research output: Contribution to journalArticle


Introduction: We evaluated whether incident mild cognitive impairment (MCI) subtypes could be empirically derived in the Mayo Clinic Study of Aging. Methods: We performed cluster analysis on neuropsychological data from 506 participants with incident MCI. Results: The 3-cluster solution resulted in (1) amnestic, (2) dysexecutive, (3) dysnomic subtypes. The 4-cluster solution produced these same three groups and a fourth group with subtle cognitive impairment (SCI). The SCI cluster was a subset of the amnestic cluster and distinct from well-matched cognitively unimpaired participants based on memory and global z-score area under the receiver operating characteristic curve analyses and probability of progression to MCI/dementia. Discussion: We empirically identified three neuropsychological subtypes of MCI that share some features with MCI subtypes identified in the Alzheimer's Disease Neuroimaging Initiative. The fourth subtype with SCI in the Mayo Clinic Study of Aging differed from the fourth cluster-derived normal group in Alzheimer's Disease Neuroimaging Initiative and could represent a group to target with early interventions.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
StatePublished - Jan 1 2019



  • Cluster analysis
  • MCI
  • Mild cognitive impairment
  • Neuropsychology
  • Subtle cognitive impairment

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

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