Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment

ISTAART Neuropsychiatric Symptoms Professional Interest Area

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

Neuropsychiatric symptoms (NPS) are common in dementia and in predementia syndromes such as mild cognitive impairment (MCI). NPS in MCI confer a greater risk for conversion to dementia in comparison to MCI patients without NPS. NPS in older adults with normal cognition also confers a greater risk of cognitive decline in comparison to older adults without NPS. Mild behavioral impairment (MBI) has been proposed as a diagnostic construct aimed to identify patients with an increased risk of developing dementia, but who may or may not have cognitive symptoms. We propose criteria that include MCI in the MBI framework, in contrast to prior definitions of MBI. Although MBI and MCI can co-occur, we suggest that they are different and that both portend a higher risk of dementia. These MBI criteria extend the previous literature in this area and will serve as a template for validation of the MBI construct from epidemiologic, neurobiological, treatment, and prevention perspectives.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalAlzheimer's and Dementia
Volume12
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • Agitation
  • Alzheimer's disease
  • Apathy
  • BPSD
  • Behavior
  • Behaviour
  • Dementia
  • Depression
  • Disinhibition
  • FTD
  • MBI
  • MCI
  • NPS
  • Neuropsychiatric symptoms of dementia
  • Psychosis

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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