Neuromyelitis optica spectrum disorders

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Neuromyelitis optica is an uncommon inflammatory demyelinating CNS disorder that is distinct from multiple sclerosis with respect to clinical, laboratory, neuroimaging, and prognostic characteristics. Autoantibodies that target aquaporin-4 are highly specific for neuromyelitis optica and have helped define a spectrumof disease beyond the classic definition of acute transverse myelitis and optic neuritis. Accumulating evidence supports the pathogenic potential that these autoantibodies possess in relation to the unique vasculocentric immunopathology of the disease. Current treatment strategies therefore include the use of corticosteroids and plasmapheresis for acute attacks and general or humoral immunosuppression for attack prevention. Ongoing research will focus on establishing the pathogenic mechanisms of the disease, in part derived from newly reported animal models, and testing-focused treatment strategies that evolve from this knowledge.

Original languageEnglish (US)
Pages (from-to)105-121
Number of pages17
JournalCONTINUUM Lifelong Learning in Neurology
Volume16
Issue number5
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

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