Neuromyelitis optica: Potential roles for intravenous immunoglobulin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Neuromyelitis optica (NMO) is an idiopathic central nervous system inflammatory demyelinating disease that causes optic neuritis, transverse myelitis, and other CNS syndromes. It is distinct from multiple sclerosis and is associated with autoantibodies that target aquaporin-4 (AQP4), an astrocyte water channel. Evidence indicating antibody-mediated immune injury in NMO includes its association with other autoimmune diseases, lesional pathology that reveals prominent complement activation and immunoglobulin deposition, pathogenic potential of AQP4 autoantibodies based on in vitro studies, and reports of putative animal models of the disease. The rationale and potential role for intravenous immunoglobulin in NMO will be discussed in the context of both relapse treatment and relapse prevention.

Original languageEnglish (US)
JournalJournal of Clinical Immunology
Volume33
Issue numberSUPPL.1
DOIs
StatePublished - Jan 2013

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Neuromyelitis Optica
Intravenous Immunoglobulins
Aquaporin 4
Autoantibodies
Transverse Myelitis
Animal Disease Models
Optic Neuritis
Aquaporins
Complement Activation
Demyelinating Diseases
Secondary Prevention
Astrocytes
Autoimmune Diseases
Multiple Sclerosis
Immunoglobulins
Central Nervous System
Pathology
Recurrence
Antibodies
Wounds and Injuries

Keywords

  • aquaporin-4
  • intravenous immunoglobulin
  • Neuromyelitis optica

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Neuromyelitis optica : Potential roles for intravenous immunoglobulin. / Wingerchuk, Dean Marko.

In: Journal of Clinical Immunology, Vol. 33, No. SUPPL.1, 01.2013.

Research output: Contribution to journalArticle

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