Neuromuscular transmission failure during postnatal development

Mario Fournier; Mahlet Alula; Gary C. Sieck

doi:10.1016/0304-3940(91)90124-C

Neuromuscular transmission failure during postnatal development

Mario Fournier, Mahlet Alula, Gary C. Sieck

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Neuromuscular transmission failure in rat diaphragm muscle was examined during the first two weeks of postnatal development, and was found to contribute significantly more to diaphragm fatigue induced by repetitive activation than in adult muscle. Intracellular analysis of evoked end-plate potentials indicated that neuromuscular transmission failure was due to both a block of action potential propagation and reduced synaptic efficacy.

Original language	English (US)
Pages (from-to)	34-36
Number of pages	3
Journal	Neuroscience Letters
Volume	125
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90124-C
State	Published - Apr 15 1991

Keywords

Development
Diaphragm muscle
End-plate potential
Fatigue
Neuromuscular junction
Phrenic nerve

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90124-C

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title = "Neuromuscular transmission failure during postnatal development",

abstract = "Neuromuscular transmission failure in rat diaphragm muscle was examined during the first two weeks of postnatal development, and was found to contribute significantly more to diaphragm fatigue induced by repetitive activation than in adult muscle. Intracellular analysis of evoked end-plate potentials indicated that neuromuscular transmission failure was due to both a block of action potential propagation and reduced synaptic efficacy.",

keywords = "Development, Diaphragm muscle, End-plate potential, Fatigue, Neuromuscular junction, Phrenic nerve",

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AU - Fournier, Mario

AU - Alula, Mahlet

AU - Sieck, Gary C.

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N2 - Neuromuscular transmission failure in rat diaphragm muscle was examined during the first two weeks of postnatal development, and was found to contribute significantly more to diaphragm fatigue induced by repetitive activation than in adult muscle. Intracellular analysis of evoked end-plate potentials indicated that neuromuscular transmission failure was due to both a block of action potential propagation and reduced synaptic efficacy.

AB - Neuromuscular transmission failure in rat diaphragm muscle was examined during the first two weeks of postnatal development, and was found to contribute significantly more to diaphragm fatigue induced by repetitive activation than in adult muscle. Intracellular analysis of evoked end-plate potentials indicated that neuromuscular transmission failure was due to both a block of action potential propagation and reduced synaptic efficacy.

KW - Development

KW - Diaphragm muscle

KW - End-plate potential

KW - Fatigue

KW - Neuromuscular junction

KW - Phrenic nerve

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Neuromuscular transmission failure during postnatal development

Abstract

Keywords

ASJC Scopus subject areas

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