Neuromuscular transmission failure during postnatal development

Mario Fournier, Mahlet Alula, Gary C. Sieck

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Neuromuscular transmission failure in rat diaphragm muscle was examined during the first two weeks of postnatal development, and was found to contribute significantly more to diaphragm fatigue induced by repetitive activation than in adult muscle. Intracellular analysis of evoked end-plate potentials indicated that neuromuscular transmission failure was due to both a block of action potential propagation and reduced synaptic efficacy.

Original languageEnglish (US)
Pages (from-to)34-36
Number of pages3
JournalNeuroscience Letters
Issue number1
StatePublished - Apr 15 1991


  • Development
  • Diaphragm muscle
  • End-plate potential
  • Fatigue
  • Neuromuscular junction
  • Phrenic nerve

ASJC Scopus subject areas

  • Neuroscience(all)


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