TY - JOUR
T1 - Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum
AU - Freilich, Robert W.
AU - Ikezu, Tsuneya
N1 - Funding Information:
Acknowledgment We would like to thank Drs. Sulie Chang and Howard Gendelman for the opportunity to write this manuscript, Mrs. Robin Taylor for editorial assistance. This work is partly funded by NIH (5T32GM008541 to RWF, R01 MH072539, and R21 AG032600 to TI) and Boston University Faculty Recruit Fund (TI).
Funding Information:
Source of Support Support, in part, by NIH grant 5T32GM008541 to RWF, R01 MH072539, and R21 AG032600 to TI Electronic supplementary material The online version of this article (doi:10.1007/s11481-010-9250-7) contains supplementary material, which is available to authorized users. R.W.Freilich(*) . T. Ikezu (*) Laboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 72 E. Concord St. L-606, Boston, MA 02118, USA e-mail: robf999@bu.edu
PY - 2011/3
Y1 - 2011/3
N2 - The emerging field of neuroimmune pharmacology (NIP) is the confluence of three distinct disciplines: neuroscience, immunology, and pharmacology (Gendelman and Ikezu 2008). NIP was born from the realization that inflammation within the central nervous system (CNS) plays a crucial role in many neurological pathologies and as such offers a rich array of novel pharmacological targets as potential therapeutics. As this field is likely to have a major impact in medical science, educating future physicians on this area will help increase awareness and may potentially inspire them to pursue careers in the field of NIP. However, a key challenge for medical educators, is how best to incorporate new material on emerging fields, such as NIP, into the medical school curriculum, specifically in the context of a medical neuroscience course. We propose the addition of two 50-min lectures plus an additional optional 2-h lab module to the standard first year medical neuroscience class curriculum. Lecture 1 will focus on how the CNS and the immune system inter-communicate with one another with emphasis on neuroanatomical features and chemical signal transduction between the two systems. Lecture 2 provides an introduction to inflammation in the CNS and provides a series of clinical correlates to describe how CNS inflammation contributes to the disease process. The lab module provides detailed visual examples of how CNS inflammation influences disease processes and provides two examples of how application of an immunomodulatory pharmacological agent can modify disease processes.
AB - The emerging field of neuroimmune pharmacology (NIP) is the confluence of three distinct disciplines: neuroscience, immunology, and pharmacology (Gendelman and Ikezu 2008). NIP was born from the realization that inflammation within the central nervous system (CNS) plays a crucial role in many neurological pathologies and as such offers a rich array of novel pharmacological targets as potential therapeutics. As this field is likely to have a major impact in medical science, educating future physicians on this area will help increase awareness and may potentially inspire them to pursue careers in the field of NIP. However, a key challenge for medical educators, is how best to incorporate new material on emerging fields, such as NIP, into the medical school curriculum, specifically in the context of a medical neuroscience course. We propose the addition of two 50-min lectures plus an additional optional 2-h lab module to the standard first year medical neuroscience class curriculum. Lecture 1 will focus on how the CNS and the immune system inter-communicate with one another with emphasis on neuroanatomical features and chemical signal transduction between the two systems. Lecture 2 provides an introduction to inflammation in the CNS and provides a series of clinical correlates to describe how CNS inflammation contributes to the disease process. The lab module provides detailed visual examples of how CNS inflammation influences disease processes and provides two examples of how application of an immunomodulatory pharmacological agent can modify disease processes.
KW - Education
KW - Medical school curriculum
KW - Medical students
KW - Neuroimmune pharmacology
KW - Neuroscience
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U2 - 10.1007/s11481-010-9250-7
DO - 10.1007/s11481-010-9250-7
M3 - Review article
C2 - 21103946
AN - SCOPUS:79251648284
SN - 1557-1890
VL - 6
SP - 41
EP - 56
JO - Journal of Neuroimmune Pharmacology
JF - Journal of Neuroimmune Pharmacology
IS - 1
ER -