Abstract
The most effective treatment for drug-resistant seizures associated with mesial temporal lobe epilepsy (mTLE) is surgical resection. Neurocognitive sequelae may occur and are especially likely to occur after left temporal lobectomy. Smaller resections observed with selective amygdalohippocampectomy have resulted in a more favorable neurocognitive outcome in some cases when compared to standard anterior temporal lobectomy. Specifically, MRI-guided interstitial laser thermal ablation (MRgLITT) uses a superselective stereotactic amygdalohippocampotomy that has been reported to preserve object recognition and naming abilities compared with standard temporal lobe resection. We report two patients with drug-resistant mTLE and a normal high-resolution 3-T brain MRI who underwent neuropsychological assessment pre- and postleft temporal MRgLITT. Both patients demonstrated preserved visual naming ability following surgery. Semantic verbal fluency declined after surgery, but the magnitude of decline did not reach the statistical threshold for reliable change. Both patients demonstrated statistically significant and clinically meaningful declines in memory, but abilities across other nonmemory neurocognitive domains (i.e., visuospatial ability, attention) were preserved.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 44-47 |
| Number of pages | 4 |
| Journal | Epilepsy and Behavior |
| Volume | 56 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- Anterior temporal lobectomy
- Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT)
- MRI-, PET+
- Neurocognitive
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Clinical Neurology
- Behavioral Neuroscience
- Neurology
Cite this
Neurocognitive outcome following stereotactic laser ablation in two patients with MRI-/PET+ mTLE. / Dredla, Brynn; Lucas, John A; Wharen, Rober E.; Tatum, William O.
In: Epilepsy and Behavior, Vol. 56, 01.03.2016, p. 44-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurocognitive outcome following stereotactic laser ablation in two patients with MRI-/PET+ mTLE
AU - Dredla, Brynn
AU - Lucas, John A
AU - Wharen, Rober E.
AU - Tatum, William O.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - The most effective treatment for drug-resistant seizures associated with mesial temporal lobe epilepsy (mTLE) is surgical resection. Neurocognitive sequelae may occur and are especially likely to occur after left temporal lobectomy. Smaller resections observed with selective amygdalohippocampectomy have resulted in a more favorable neurocognitive outcome in some cases when compared to standard anterior temporal lobectomy. Specifically, MRI-guided interstitial laser thermal ablation (MRgLITT) uses a superselective stereotactic amygdalohippocampotomy that has been reported to preserve object recognition and naming abilities compared with standard temporal lobe resection. We report two patients with drug-resistant mTLE and a normal high-resolution 3-T brain MRI who underwent neuropsychological assessment pre- and postleft temporal MRgLITT. Both patients demonstrated preserved visual naming ability following surgery. Semantic verbal fluency declined after surgery, but the magnitude of decline did not reach the statistical threshold for reliable change. Both patients demonstrated statistically significant and clinically meaningful declines in memory, but abilities across other nonmemory neurocognitive domains (i.e., visuospatial ability, attention) were preserved.
AB - The most effective treatment for drug-resistant seizures associated with mesial temporal lobe epilepsy (mTLE) is surgical resection. Neurocognitive sequelae may occur and are especially likely to occur after left temporal lobectomy. Smaller resections observed with selective amygdalohippocampectomy have resulted in a more favorable neurocognitive outcome in some cases when compared to standard anterior temporal lobectomy. Specifically, MRI-guided interstitial laser thermal ablation (MRgLITT) uses a superselective stereotactic amygdalohippocampotomy that has been reported to preserve object recognition and naming abilities compared with standard temporal lobe resection. We report two patients with drug-resistant mTLE and a normal high-resolution 3-T brain MRI who underwent neuropsychological assessment pre- and postleft temporal MRgLITT. Both patients demonstrated preserved visual naming ability following surgery. Semantic verbal fluency declined after surgery, but the magnitude of decline did not reach the statistical threshold for reliable change. Both patients demonstrated statistically significant and clinically meaningful declines in memory, but abilities across other nonmemory neurocognitive domains (i.e., visuospatial ability, attention) were preserved.
KW - Anterior temporal lobectomy
KW - Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT)
KW - MRI-, PET+
KW - Neurocognitive
KW - Temporal lobe epilepsy
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UR - http://www.scopus.com/inward/citedby.url?scp=84956670010&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2015.12.047
DO - 10.1016/j.yebeh.2015.12.047
M3 - Article
C2 - 26828690
AN - SCOPUS:84956670010
VL - 56
SP - 44
EP - 47
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
ER -