Neural and hormonal control of pyloric sphincter function

L. M.A. Akkermans, L. A. Houghton, N. J. Brown

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Recent manometric studies suggest that the pylorus functions in conjunction with the stomach and duodenum to regulate gastric emptying of both solids and liquids. The opening of the pylorus is controlled intramurally by contractions in the antrum and either Immorally or neurally by the presence of food or acid in the duodenum. Vagal excitation of the pylorus is mediated by both cholinergic and non-cholinergic, non-adrenergic (NANC) (possibly enkephalinergic) pathways, whereas vagal relaxation is mediated by a NANC pathway with vasointestinal polypeptide (VIP) as the possible neurotransmitter. Sympathetic excitation of the pylorus is mediated by postganglionic cholinergic fibres and by beta-receptor acetylcholine release, whereas sympathetic inhibition is mediated by both alpha- and beta-receptors. Cholecystokinin administered in physiologic doses induces phasic contractions of the pylorus by a direct action and tonic contractions via a non-cholinergic pathway. Finally, disordered neural and hormonal control of the pylorus may result in disturbed pyloric activity, as seen in diabetic gastropareses and in hypertrophic pyloric stenosis.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume24
Issue numberS171
DOIs
StatePublished - Jan 1 1989

Keywords

  • Gastrointestinal hormones
  • Gastrointestinal motility
  • Pyloric physiology

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Neural and hormonal control of pyloric sphincter function'. Together they form a unique fingerprint.

Cite this