NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

David L. Porter, Edwin P. Alyea, Joseph H. Antin, Marcos DeLima, Eli Estey, J. H.Frederik Falkenburg, Nancy Hardy, Nicolaus Kroeger, Jose Leis, John Levine, David G. Maloney, Karl Peggs, Jacob M. Rowe, Alan S. Wayne, Sergio Giralt, Michael R. Bishop, Koen van Besien

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations

Abstract

Relapse is a major cause of treatment failure after allogeneic hematopoietic stem cell transplantation (alloHSCT). Treatment options for relapse have been inadequate, and the majority of patients ultimately die of their disease. There is no standard approach to treating relapse after alloHSCT. Withdrawal of immune suppression and donor lymphocyte infusions are commonly used for all diseases; although these interventions are remarkably effective for relapsed chronic myelogenous leukemia, they have limited efficacy in other hematologic malignancies. Conventional and novel chemotherapy, monoclonal antibody therapy, targeted therapies, and second transplants have been utilized in a variety of relapsed diseases, but reports on these therapies are generally anecdotal and retrospective. As such, there is an immediate need for well-designed, disease-specific trials for treatment of relapse after alloHSCT. This report summarizes current treatment options under investigation for relapse after alloHSCT in a disease-specific manner. In addition, recommendations are provided for specific areas of research necessary in the treatment of relapse after alloHSCT.

Original languageEnglish (US)
Pages (from-to)1467-1503
Number of pages37
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Donor lymphocyte infusion
  • Treatment

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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