Natural history of benign prostatic enlargement

Long-term longitudinal population-based study of prostate volume doubling times

Michael M. Lieber, Thomas Rhodes, Debra J. Jacobson, Michaela E. McGree, Cynthia J. Girman, Steven J. Jacobsen, Jennifer St. Sauver

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVES To measure prostate volume doubling times (PVDTs) for a large sample of community men followed serially by transrectal ultrasonography (TRUS), and to determine whether specific characteristics are associated with a rapid PVDT. SUBJECTS AND METHODS A subsample of 446 subjects from a larger cohort of American white men aged 40-79 years were evaluated biennially for a median (range) follow-up of 10 (3-14) years. Mixed-effects regression models were used to estimate prostate growth rates and PVDT for subjects with three or more or with five or more serial biennial TRUS PV measurements. Results The median (25-75th percentile) PVDT was 32.6 (24.6-44.0) years. The average annual increase in PV was 2.2%. The PVDT distribution was constant in men of all age groups studied (r < 0.001, P = 0.99). The factor most strongly associated with PVDT was baseline transition zone volume (r = -0.55, P < 0.001). Baseline total prostate-specific antigen (PSA) level, free PSA and total PV were also significantly inversely associated with PVDT (r = -0.30, -0.44 and -0.32, respectively, all P < 0.001). Age, baseline anthropomorphic measurements, hormone levels and specific lifestyle characteristics were not significantly correlated with PVDT. Conclusion These data indicate that PVDT might be a useful future measure of benign prostatic growth. They provide a basis to forecast PV at 10, 20, or 30 years later, after one baseline TRUS measurement of prostate volume, and can be presented in a simple nomogram.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalBJU International
Volume105
Issue number2
DOIs
StatePublished - Jan 2010

Fingerprint

Natural History
Prostate
Population
Ultrasonography
Prostate-Specific Antigen
Nomograms
Growth
Life Style
Age Groups
Hormones

Keywords

  • Benign prostate enlargement
  • Prostate growth rates

ASJC Scopus subject areas

  • Urology

Cite this

Natural history of benign prostatic enlargement : Long-term longitudinal population-based study of prostate volume doubling times. / Lieber, Michael M.; Rhodes, Thomas; Jacobson, Debra J.; McGree, Michaela E.; Girman, Cynthia J.; Jacobsen, Steven J.; St. Sauver, Jennifer.

In: BJU International, Vol. 105, No. 2, 01.2010, p. 214-219.

Research output: Contribution to journalArticle

Lieber, Michael M. ; Rhodes, Thomas ; Jacobson, Debra J. ; McGree, Michaela E. ; Girman, Cynthia J. ; Jacobsen, Steven J. ; St. Sauver, Jennifer. / Natural history of benign prostatic enlargement : Long-term longitudinal population-based study of prostate volume doubling times. In: BJU International. 2010 ; Vol. 105, No. 2. pp. 214-219.
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