Nanotherapeutic systems for local treatment of brain tumors

Rami Walid Chakroun, Pengcheng Zhang, Ran Lin, Paula Schiapparelli, Alfredo Quinones-Hinojosa, Honggang Cui

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Malignant brain tumor, including the most common type glioblastoma, are histologically heterogeneous and invasive tumors known as the most devastating neoplasms with high morbidity and mortality. Despite multimodal treatment including surgery, radiotherapy, chemotherapy, and immunotherapy, the disease inevitably recurs and is fatal. This lack of curative options has motivated researchers to explore new treatment strategies and to develop new drug delivery systems (DDSs); however, the unique anatomical, physiological, and pathological features of brain tumors greatly limit the effectiveness of conventional chemotherapy. In this context, we review the recent progress in the development of nanoparticle-based DDSs aiming to address the key challenges in transporting sufficient amount of therapeutic agents into the brain tumor areas while minimizing the potential side effects. We first provide an overview of the standard treatments currently used in the clinic for the management of brain cancers, discussing the effectiveness and limitations of each therapy. We then provide an in-depth review of nanotherapeutic systems that are intended to bypass the blood-brain barrier, overcome multidrug resistance, infiltrate larger tumorous tissue areas, and/or release therapeutic agents in a controlled manner. For further resources related to this article, please visit the WIREs website.

Original languageEnglish (US)
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
DOIs
StateAccepted/In press - 2017

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Brain Neoplasms
Tumors
Brain
Chemotherapy
Drug Delivery Systems
Radiotherapy
Therapeutics
Drug Therapy
Combined Modality Therapy
Surgery
Websites
Multiple Drug Resistance
Glioblastoma
Blood-Brain Barrier
Immunotherapy
Nanoparticles
Tissue
Neoplasms
Research Personnel
Morbidity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering

Cite this

Nanotherapeutic systems for local treatment of brain tumors. / Chakroun, Rami Walid; Zhang, Pengcheng; Lin, Ran; Schiapparelli, Paula; Quinones-Hinojosa, Alfredo; Cui, Honggang.

In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017.

Research output: Contribution to journalArticle

Chakroun, Rami Walid ; Zhang, Pengcheng ; Lin, Ran ; Schiapparelli, Paula ; Quinones-Hinojosa, Alfredo ; Cui, Honggang. / Nanotherapeutic systems for local treatment of brain tumors. In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2017.
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