N-butyrate increases c-erb A oncogene expression in human colon fibroblasts

Rebecca S. Bahn, Jay C. Zeller, Terry J. Smith

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number1
DOIs
StatePublished - Jan 15 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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