We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jan 15 1988|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology