N-butyrate increases c-erb A oncogene expression in human colon fibroblasts

Rebecca S. Bahn, Jay C. Zeller, Terry J. Smith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number1
DOIs
StatePublished - Jan 15 1988

Fingerprint

Butyrates
Fibroblasts
Oncogenes
Actins
Colon
Demonstrations
Complementary DNA
Genes
RNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

N-butyrate increases c-erb A oncogene expression in human colon fibroblasts. / Bahn, Rebecca S.; Zeller, Jay C.; Smith, Terry J.

In: Biochemical and Biophysical Research Communications, Vol. 150, No. 1, 15.01.1988, p. 259-262.

Research output: Contribution to journalArticle

Bahn, Rebecca S. ; Zeller, Jay C. ; Smith, Terry J. / N-butyrate increases c-erb A oncogene expression in human colon fibroblasts. In: Biochemical and Biophysical Research Communications. 1988 ; Vol. 150, No. 1. pp. 259-262.
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