N-butyrate increases c-erb A oncogene expression in human colon fibroblasts

Rebecca S. Bahn; Jay C. Zeller; Terry J. Smith

doi:10.1016/0006-291X(88)90514-1

N-butyrate increases c-erb A oncogene expression in human colon fibroblasts

Rebecca S. Bahn, Jay C. Zeller, Terry J. Smith

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	150
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(88)90514-1
State	Published - Jan 15 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.",

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AU - Zeller, Jay C.

AU - Smith, Terry J.

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N2 - We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.

AB - We investigated the effect of n-butyrate (2.5 mM) on expression of the c-erb A oncogene in human colon fibroblasts. Exposure of these cells to the compound for 48 hours resulted in an increased accumulation of approximately 2.0 kb RNA which hybridized to a v-erb A cDNA probe. Hybridization to a β-actin gene probe was unaffected by the treatment. This report is the first demonstration of a factor affecting expression of the c-erb A oncogene.

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N-butyrate increases c-erb A oncogene expression in human colon fibroblasts

Abstract

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