Research output: Chapter in Book/Report/Conference proceedingChapter


Hereditary influences have long been considered a component in the etiology of glaucoma, considering that relatives of individuals clinically diagnosed with juvenile open-angle glaucoma (JOAG) and primary open-angle glaucoma (POAG) have a higher incidence of the disease. The first described gene with an association to JOAG and POAG was myocilin, a 504-amino-acid glycoprotein. Mutations within myocilin are associated with up to 36% of JOAG and 4% of POAG cases. The function of myocilin in normal or glaucoma eyes is unknown.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Eye
Number of pages8
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
StatePublished - Jan 1 2010


  • Anterior segment
  • Aqueous humor
  • Extracellular matrix
  • Glaucoma
  • Intraocular pressure
  • Juvenile open-angle glaucoma (JOAG)
  • Myocilin
  • Olfactomedin
  • Primary open-angle glaucoma (POAG)
  • Trabecular meshwork
  • Trabecular meshwork inducible glucocorticoid response gene (TIGR)

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Myocilin'. Together they form a unique fingerprint.

Cite this