Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease

Robert H. Nelson, Abhiram Prasad, Amir Lerman, John M. Miles

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Animal studies indicate that oversupply of fatty acids derived from the action of cardiac lipoprotein lipase (LPL) on plasma lipoproteins may contribute to myocardial dysfunction. However, the contribution of circulating triglycerides to myocardial fatty acid supply in humans is not known. Six postabsorptive nondiabetic subjects who were scheduled for diagnostic coronary angiography were studied. 14C oleate and a lipid emulsion labeled with 3H triolein were infused to assess myocardial uptake of free fatty acids (FFAs) and triglycerides, as well as myocardial spillover of LPL-generated fatty acids. Six paired blood samples were taken from the femoral artery and the coronary sinus. Coronary sinus concentrations of unlabeled triglycerides were slightly, but not significantly, lower than arterial (P = 0.12), whereas labeled triglyceride concentrations were significantly lower in the coronary sinus than in the artery (P < 0.05; extraction fraction ≅11%). Triglycerides and FFAs accounted for ∼17% and ∼83%, respectively, of myocardial fatty acid uptake. Systemic and myocardial fractional spillover of LPL-generated fatty acids was 49.0 ± 7% and 34.7 ± 13%, respectively. The myocardium was a minor contributor to systemic triglyceride uptake (∼3%) and a trivial contributor to systemic FFA production (∼0.5%). These results indicate that circulating triglycerides may be a significant source of fatty acids for myocardial respiration.

Original languageEnglish (US)
Pages (from-to)527-530
Number of pages4
JournalDiabetes
Volume56
Issue number2
DOIs
StatePublished - Feb 2007

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Heart Diseases
Triglycerides
Fatty Acids
Coronary Sinus
Lipoprotein Lipase
Nonesterified Fatty Acids
Triolein
Femoral Artery
Oleic Acid
Emulsions
Coronary Angiography
Lipoproteins
Myocardium
Respiration
Arteries
Lipids

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. / Nelson, Robert H.; Prasad, Abhiram; Lerman, Amir; Miles, John M.

In: Diabetes, Vol. 56, No. 2, 02.2007, p. 527-530.

Research output: Contribution to journalArticle

Nelson, Robert H. ; Prasad, Abhiram ; Lerman, Amir ; Miles, John M. / Myocardial uptake of circulating triglycerides in nondiabetic patients with heart disease. In: Diabetes. 2007 ; Vol. 56, No. 2. pp. 527-530.
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