Myocardial recovery in peripartum cardiomyopathy: Prospective comparison with recent onset cardiomyopathy in men and nonperipartum women

Leslie T. Cooper, Paul J. Mather, Jeffrey D. Alexis, Daniel F. Pauly, Guillermo Torre-Amione, Ilan S. Wittstein, G. William Dec, Mark Zucker, Jagat Narula, Kevin Kip, Dennis M. McNamara

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Background: Whether myocardial recovery occurs more frequently in peripartum cardiomyopathy (PPCM) than in recent onset cardiomyopathies in men and nonperipartum women has not been prospectively evaluated. This was examined through an analysis of outcomes in the Intervention in Myocarditis and Acute Cardiomyopathy 2 (IMAC2) registry. Methods and Results: IMAC2 enrolled 373 subjects with recent onset nonischemic dilated cardiomyopathy. Left ventricular ejection fraction (LVEF) was assessed at entry and 6 months, and subjects followed for up to 4 years. Myocardial recovery was compared between men (group 1), nonperipartum women (group 2) and subjects with PPCM (group 3). The cohort included 230 subjects in group 1, 104 in group 2, and 39 in group 3. The mean LVEF at baseline in groups 1, 2, and 3 was 0.23 ± 0.08, 0.24 ± 0.08, and 0.27 ± 0.07 (P =.04), and at 6 months was 0.39 ± 0.12, 0.42 ± 0.11, and 0.45 ± 0.14 (P =.007). Subjects in group 3 had a much greater likelihood of achieving an LVEF >0.50 at 6 months than groups 1 or 2 (19 %, 34%, and 48% respectively, P =.002). Conclusions: Prospective evaluation confirms myocardial recovery is greatest in women with PPCM, poorest in men, and intermediate in nonperipartum women. On contemporary therapy, nearly half of women with PPCM normalize cardiac function by 6 months.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalJournal of Cardiac Failure
Volume18
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Heart failure
  • dilated cardiomyopathy
  • myocardial recovery
  • outcomes
  • pregnancy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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