Mutations in the dimer interface of dihydrolipoamide dehydrogenase promote site-specific oxidative damages in yeast and human cells

Medicine & Life Sciences

• Dihydrolipoamide Dehydrogenase 97%
• Yeasts 50%
• Mutation 34%
• Oxidoreductases 15%
• Thioctic Acid 15%
• Pyruvic Acid 12%
• Ketoglutarate Dehydrogenase Complex 8%
• Oxidative Stress 8%
• Phenotype 6%
• Serine Proteases 6%
• Proteins 6%
• NAD 5%
• Catalytic Domain 5%
• Fibroblasts 4%
• In Vitro Techniques 2%

Chemical Compounds

• Dihydrolipoamide 100%
• Mutation 52%
• Lipoic Acid 15%
• Pyruvate 11%
• Oxidative Stress 11%
• Cofactor 10%
• Protein 7%
• Serine 5%
• Disorder 4%
• Molecule 1%