Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

Wanguo Liu; Xiangyang Dong; Ming Mai; Ratnam S. Seelan; Ken Taniguchi; Kausilia K. Krishnadath; Kevin C. Halling; Julie M. Cunningham; Chiping Qian; Eric Christensen; Patrick C. Roche; David I. Smith; Stephen N. Thibodeau

doi:10.1038/79859

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

Wanguo Liu, Xiangyang Dong, Ming Mai, Ratnam S. Seelan, Ken Taniguchi, Kausilia K. Krishnadath, Kevin C. Halling, Julie M. Cunningham, Chiping Qian, Eric Christensen, Patrick C. Roche, David I. Smith, Stephen N. Thibodeau

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

413 Scopus citations

Original language	English (US)
Pages (from-to)	146-147
Number of pages	2
Journal	Nature Genetics
Volume	26
Issue number	2
DOIs	https://doi.org/10.1038/79859
State	Published - Oct 2000

ASJC Scopus subject areas

Genetics

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Liu, W., Dong, X., Mai, M., Seelan, R. S., Taniguchi, K., Krishnadath, K. K., Halling, K. C., Cunningham, J. M., Qian, C., Christensen, E., Roche, P. C., Smith, D. I., & Thibodeau, S. N. (2000). Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling. Nature Genetics, 26(2), 146-147. https://doi.org/10.1038/79859

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title = "Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling",

author = "Wanguo Liu and Xiangyang Dong and Ming Mai and Seelan, {Ratnam S.} and Ken Taniguchi and Krishnadath, {Kausilia K.} and Halling, {Kevin C.} and Cunningham, {Julie M.} and Chiping Qian and Eric Christensen and Roche, {Patrick C.} and Smith, {David I.} and Thibodeau, {Stephen N.}",

note = "Funding Information: These studies were carried out with the support of funds from Mayo Clinic/Foundation to W.L. and by grants from the National Institutes of Health to D.I.S. (CA 48031) and S.N.T. (CA 60117). Funding Information: We thank H. Poinar for discussions and synthesis of PTB; C. F{\"a}rber and S. Gross for technical support; W. Schartau for primer synthesis; J. Bark and P. Gill for experimental help; K. Strimmer and F. Burckhardt for help with databases and computer programs; A. Greenwood, J. Hey, S. Hornung, M. Stoneking, L. Vigilant and D. Serre for help and discussions; and the Deutsche Forschungsgemeinschaft and the Max Planck Gesellschaft for financial support.",

year = "2000",

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doi = "10.1038/79859",

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T1 - Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

AU - Liu, Wanguo

AU - Dong, Xiangyang

AU - Mai, Ming

AU - Seelan, Ratnam S.

AU - Taniguchi, Ken

AU - Krishnadath, Kausilia K.

AU - Halling, Kevin C.

AU - Cunningham, Julie M.

AU - Qian, Chiping

AU - Christensen, Eric

AU - Roche, Patrick C.

AU - Smith, David I.

AU - Thibodeau, Stephen N.

N1 - Funding Information: These studies were carried out with the support of funds from Mayo Clinic/Foundation to W.L. and by grants from the National Institutes of Health to D.I.S. (CA 48031) and S.N.T. (CA 60117). Funding Information: We thank H. Poinar for discussions and synthesis of PTB; C. Färber and S. Gross for technical support; W. Schartau for primer synthesis; J. Bark and P. Gill for experimental help; K. Strimmer and F. Burckhardt for help with databases and computer programs; A. Greenwood, J. Hey, S. Hornung, M. Stoneking, L. Vigilant and D. Serre for help and discussions; and the Deutsche Forschungsgemeinschaft and the Max Planck Gesellschaft for financial support.

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JO - Nature Genetics

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

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