Mutagen sensitivity and risk of gliomas: A case-control analysis

Melissa L. Bondy, Athanassios P. Kyritsis, Jun Gu, Mariza De Andrade, Joan Cunningham, Victor A. Levin, Janet M. Bruner, Qingyi Wei

Research output: Contribution to journalArticle

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Abstract

Although the risk factors contributing to the etiology of brain tumors remain largely unknown, this pilot study suggests that genetically determined sensitivity to environmental carcinogens may play a role in the pathogenesis of these tumors. In this study, we examined short-term lymphocyte cultures from 45 adult malignant glioma patients and 117 age-, sex-, and ethnicity- matched healthy controls for mutagen-induced chromatid breaks and evaluated their family history of cancer, smoking, and demographic variables to ascertain the association between mutagen sensitivity and risk of brain tumors. The mutagen selected was γ-radiation. The mean number of induced breaks/cell was 0.72 (SD = 0.45) for the cases and 0.45 (SD = 0.35) for the controls (P < 0.0001). Using the median number of induced breaks/cell in the controls as the breakpoint for defining mutagen sensitivity, we observed an unadjusted odds ratio of 5.36 (95% confidence interval = 2.12-13.69) for mutagen sensitivity and brain tumor risk and an adjusted odds ratio of 5.79 (2.26-14.83), when we controlled for epidemiological risk factors including smoking, race, income, and education. Although a larger study is needed to confirm this intriguing result, these preliminary findings suggest that increased sensitivity to radiation is an independent risk factor for gliomas.

Original languageEnglish (US)
Pages (from-to)1484-1486
Number of pages3
JournalCancer Research
Volume56
Issue number7
StatePublished - Apr 1 1996
Externally publishedYes

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Mutagens
Glioma
Brain Neoplasms
Smoking
Odds Ratio
Environmental Carcinogens
Chromatids
Radiation Tolerance
Neoplasms
Demography
Lymphocytes
Confidence Intervals
Radiation
Education

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bondy, M. L., Kyritsis, A. P., Gu, J., De Andrade, M., Cunningham, J., Levin, V. A., ... Wei, Q. (1996). Mutagen sensitivity and risk of gliomas: A case-control analysis. Cancer Research, 56(7), 1484-1486.

Mutagen sensitivity and risk of gliomas : A case-control analysis. / Bondy, Melissa L.; Kyritsis, Athanassios P.; Gu, Jun; De Andrade, Mariza; Cunningham, Joan; Levin, Victor A.; Bruner, Janet M.; Wei, Qingyi.

In: Cancer Research, Vol. 56, No. 7, 01.04.1996, p. 1484-1486.

Research output: Contribution to journalArticle

Bondy, ML, Kyritsis, AP, Gu, J, De Andrade, M, Cunningham, J, Levin, VA, Bruner, JM & Wei, Q 1996, 'Mutagen sensitivity and risk of gliomas: A case-control analysis', Cancer Research, vol. 56, no. 7, pp. 1484-1486.
Bondy ML, Kyritsis AP, Gu J, De Andrade M, Cunningham J, Levin VA et al. Mutagen sensitivity and risk of gliomas: A case-control analysis. Cancer Research. 1996 Apr 1;56(7):1484-1486.
Bondy, Melissa L. ; Kyritsis, Athanassios P. ; Gu, Jun ; De Andrade, Mariza ; Cunningham, Joan ; Levin, Victor A. ; Bruner, Janet M. ; Wei, Qingyi. / Mutagen sensitivity and risk of gliomas : A case-control analysis. In: Cancer Research. 1996 ; Vol. 56, No. 7. pp. 1484-1486.
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