Multiple Sclerosis: Mechanisms of Disease and Strategies for Myelin and Axonal Repair

Hernan Nicolas Lemus, Arthur E. Warrington, Moses Rodriguez

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system with a variety of presentations and unclear pathogenesis. Multiple sclerosis has been associated with the term autoimmunity as a surrogate for pathogenesis. Multiple sclerosis is an organ-specific disease with immune-mediated myelin destruction. Understanding the complex etiology of multiple sclerosis and the importance of axon integrity is critical for clinicians who treat the disease. This review discusses the immune and autoimmune aspects of multiple sclerosis based on the current published data and novel evidence of strategies that promote remyelination and protect axons.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalNeurologic clinics
Volume36
Issue number1
DOIs
StatePublished - Feb 2018

Keywords

  • Autoimmune
  • Axon
  • Immune
  • Multiple sclerosis
  • Remyelination

ASJC Scopus subject areas

  • Clinical Neurology

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