@article{4e56c71a2e1a4308aa8e6fa66ce683bd,
title = "Multiple primary malignant tumors",
abstract = "Members of colon cancer-prone nonpolyposis families who had multiple primary malignant tumors were analyzed to determine the frequencies, locations, and stages of their cancers, and the duration of their survival. Colon cancers tended to be more proximal, were in a less advanced stage than in the general population, and in a majority of instances were associated with colonic adenomas. The multiple primary malignant tumors were more common in women, and occurred at a younger age than in the general population. Six or more multiple primary malignant tumors occurred in each of 4 patients. All patients survived for more than 10 yr after the diagnosis of the first cancer. Extracolonic cancers were most frequent in the breast and endometrium.",
author = "Swaroop, {V. Santhi} and Winawer, {Sidney J.} and Kurtz, {Robert C.} and Martin Lipkin",
note = "Funding Information: Received September 2, 1986. Accepted April 6, 1987. Address requests for reprints to: Sidney J. Winawer, M.D., Chief, Gastroenterology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. This work was supported by the American Cancer Society Special Institutional Grant for Cancer Cause and Prevention Research SIG-7 and by the Gastroenterology Service of the Memorial Sloan-Kettering Cancer Center. 0 1987 by the American Gastroenterological Association 0016-5085/87/$3.50 CCs in first-degree relatives, and a third other cancer in an additional family member. No families with polyposis or a rare syndrome with cutaneous manifestations were included. Information was obtained after detailed interview of the index cases and other relatives regarding family history of cancer, inspection of death certificates and hospital records, and communication with family physicians. Among the 26 CC-prone families, 17 individuals had MPMT and had been diagnosed and followed at Memorial Sloan-Kettering Cancer Center; these individuals formed the study group. The 17 individuals with MPMT belonged to 16 of the above 26 families.",
year = "1987",
month = oct,
doi = "10.1016/0016-5085(87)90440-9",
language = "English (US)",
volume = "93",
pages = "779--783",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "4",
}