TY - JOUR
T1 - Multiple myeloma terminating in acute eosinophilic leukemia
AU - Maeda, Koichi
AU - VanSlyck, Ellis J.
AU - VanDyke, Daniel L.
PY - 1985/3/1
Y1 - 1985/3/1
N2 - A 71-year-old woman with multiple myeloma was successfully managed for 8 years with melphalan (total dose 2056 mg). She developed a refractory anemia (myelodysplastic state), which terminated in acute eosinophilic leukemia. This form of acute leukemia, induced by chemotherapy, appears to be very rare. The cytogenetic changes, including 5q- and monosomy 7, were similar to those observed in other patients with acute nonlymphocytic leukemia as a secondary malignancy following treatments of other primary tumors.
AB - A 71-year-old woman with multiple myeloma was successfully managed for 8 years with melphalan (total dose 2056 mg). She developed a refractory anemia (myelodysplastic state), which terminated in acute eosinophilic leukemia. This form of acute leukemia, induced by chemotherapy, appears to be very rare. The cytogenetic changes, including 5q- and monosomy 7, were similar to those observed in other patients with acute nonlymphocytic leukemia as a secondary malignancy following treatments of other primary tumors.
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U2 - 10.1016/0165-4608(85)90080-9
DO - 10.1016/0165-4608(85)90080-9
M3 - Article
C2 - 3971334
AN - SCOPUS:0021912875
SN - 0165-4608
VL - 16
SP - 81
EP - 89
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -