Multiple myeloma and the translocation t(11;14)(q13;q32): A report on 13 cases

Rafael Fonseca, Thomas Elmer Witzig, Morie Gertz, Robert A. Kyle, James Hoyer, Syed M. Jalal, Philip R. Greipp

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Abstract

Complex cytogenetic abnormalities have been described in patients with multple myeloma (MM). To better understand the significance of the most frequent translocation observed in MM, we studied the clinical characteristics of patients with MM and the t(11;14)(q13;q32) abnormality. A search of the cytogenetic database at the Mayo Clinic identified patients with MM and t(11;14)(q13;32). The medical records were reviewed for the clinical characteristics of these patients. We identified 13 patients with MM and t(11;14)(q13;q32) determined by standrad cytogenetic analysis; in 10 patients the abnormality was detected at the time of relapse (three with previously normal results of cytogenetic examination). At the time the translocation was detected, plasma cell (PC) leukaemia was clinically diagnosed in two patients. The median number of circulating PCs, as determined by the cytoplasmic immunofluorescence of T-cell-depleted peripheral blood mononuclear cells, was 1.1 x 109/l (mean 1.74; range 0.0017-6.26 x 109/l). On linear regression analysis there was a strong correlation between the number of circulating PCs and the number of bone marrow PCs. The median survival after demonstration of the translocation was 8.1 months. Of all patients, 10 died of disease progression and three were alive. Patients with MM who have t(11;14)(q13;q32) seem to have an agresive clinical course, even when the abnormality is detected at the time of diagnosis, with evidence of many circulating PCs.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalBritish Journal of Haematology
Volume101
Issue number2
DOIs
StatePublished - 1998

Fingerprint

Multiple Myeloma
Cytogenetics
Plasma Cell Leukemia
Cytogenetic Analysis
Chromosome Aberrations
Medical Records
Fluorescent Antibody Technique
Disease Progression
Linear Models
Blood Cells
Bone Marrow
Regression Analysis
Databases
T-Lymphocytes
Recurrence
Survival

Keywords

  • Chromosomal aberrations
  • Cyclins
  • Multiple myeloma
  • Plasmacytic leukaemia
  • Translocation (genetics)

ASJC Scopus subject areas

  • Hematology

Cite this

Multiple myeloma and the translocation t(11;14)(q13;q32) : A report on 13 cases. / Fonseca, Rafael; Witzig, Thomas Elmer; Gertz, Morie; Kyle, Robert A.; Hoyer, James; Jalal, Syed M.; Greipp, Philip R.

In: British Journal of Haematology, Vol. 101, No. 2, 1998, p. 296-301.

Research output: Contribution to journalArticle

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