Multiple common variants for celiac disease influencing immune gene expression

Patrick C.A. Dubois; Gosia Trynka; Lude Franke; Karen A. Hunt; Jihane Romanos; Alessandra Curtotti; Alexandra Zhernakova; Graham A.R. Heap; Róza Ádány; Arpo Aromaa; Maria Teresa Bardella; Leonard H. Van Den Berg; Nicholas A. Bockett; Emilio G. De La Concha; Bárbara Dema; Rudolf S.N. Fehrmann; Miguel Fernández-Arquero; Szilvia Fiatal; Elvira Grandone; Peter M. Green; Harry J.M. Groen; Rhian Gwilliam; Roderick H.J. Houwen; Sarah E. Hunt; Katri Kaukinen; Dermot Kelleher; Ilma Korponay-Szabo; Kalle Kurppa; Padraic MacMathuna; Markku Mäki; Maria Cristina Mazzilli; Owen T. McCann; M. Luisa Mearin; Charles A. Mein; Muddassar M. Mirza; Vanisha Mistry; Barbara Mora; Katherine I. Morley; Chris J. Mulder; Joseph A. Murray; Concepción Ñez; Elvira Oosterom; Roel A. Ophoff; Isabel Polanco; Leena Peltonen; Mathieu Platteel; Anna Rybak; Veikko Salomaa; Joachim J. Schweizer; Maria Pia Sperandeo; Greetje J. Tack; Graham Turner; Jan H. Veldink; Wieke H.M. Verbeek; Rinse K. Weersma; Victorien M. Wolters; Elena Urcelay; Bozena Cukrowska; Luigi Greco; Susan L. Neuhausen; Ross McManus; Donatella Barisani; Panos Deloukas; Jeffrey C. Barrett; Paivi Saavalainen; Cisca Wijmenga; David A. Van Heel

doi:10.1038/ng.543

Multiple common variants for celiac disease influencing immune gene expression

Patrick C.A. Dubois, Gosia Trynka, Lude Franke, Karen A. Hunt, Jihane Romanos, Alessandra Curtotti, Alexandra Zhernakova, Graham A.R. Heap, Róza Ádány, Arpo Aromaa, Maria Teresa Bardella, Leonard H. Van Den Berg, Nicholas A. Bockett, Emilio G. De La Concha, Bárbara Dema, Rudolf S.N. Fehrmann, Miguel Fernández-Arquero, Szilvia Fiatal, Elvira Grandone, Peter M. GreenHarry J.M. Groen, Rhian Gwilliam, Roderick H.J. Houwen, Sarah E. Hunt, Katri Kaukinen, Dermot Kelleher, Ilma Korponay-Szabo, Kalle Kurppa, Padraic MacMathuna, Markku Mäki, Maria Cristina Mazzilli, Owen T. McCann, M. Luisa Mearin, Charles A. Mein, Muddassar M. Mirza, Vanisha Mistry, Barbara Mora, Katherine I. Morley, Chris J. Mulder, Joseph A. Murray, Concepción Ñez, Elvira Oosterom, Roel A. Ophoff, Isabel Polanco, Leena Peltonen, Mathieu Platteel, Anna Rybak, Veikko Salomaa, Joachim J. Schweizer, Maria Pia Sperandeo, Greetje J. Tack, Graham Turner, Jan H. Veldink, Wieke H.M. Verbeek, Rinse K. Weersma, Victorien M. Wolters, Elena Urcelay, Bozena Cukrowska, Luigi Greco, Susan L. Neuhausen, Ross McManus, Donatella Barisani, Panos Deloukas, Jeffrey C. Barrett, Paivi Saavalainen, Cisca Wijmenga, David A. Van Heel

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Abstract

We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P_GWAS<10^-4 and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P _combined 5 × 10 ^-8); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P<0.0028, FDR 5%) with cis gene expression.

Original language	English (US)
Pages (from-to)	295-302
Number of pages	8
Journal	Nature Genetics
Volume	42
Issue number	4
DOIs	https://doi.org/10.1038/ng.543
State	Published - Apr 2010

ASJC Scopus subject areas

Genetics

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Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G. A. R., Ádány, R., Aromaa, A., Bardella, M. T., Van Den Berg, L. H., Bockett, N. A., De La Concha, E. G., Dema, B., Fehrmann, R. S. N., Fernández-Arquero, M., Fiatal, S., Grandone, E., ... Van Heel, D. A. (2010). Multiple common variants for celiac disease influencing immune gene expression. Nature Genetics, 42(4), 295-302. https://doi.org/10.1038/ng.543

Dubois, PCA, Trynka, G, Franke, L, Hunt, KA, Romanos, J, Curtotti, A, Zhernakova, A, Heap, GAR, Ádány, R, Aromaa, A, Bardella, MT, Van Den Berg, LH, Bockett, NA, De La Concha, EG, Dema, B, Fehrmann, RSN, Fernández-Arquero, M, Fiatal, S, Grandone, E, Green, PM, Groen, HJM, Gwilliam, R, Houwen, RHJ, Hunt, SE, Kaukinen, K, Kelleher, D, Korponay-Szabo, I, Kurppa, K, MacMathuna, P, Mäki, M, Mazzilli, MC, McCann, OT, Mearin, ML, Mein, CA, Mirza, MM, Mistry, V, Mora, B, Morley, KI, Mulder, CJ, Murray, JA, Ñez, C, Oosterom, E, Ophoff, RA, Polanco, I, Peltonen, L, Platteel, M, Rybak, A, Salomaa, V, Schweizer, JJ, Sperandeo, MP, Tack, GJ, Turner, G, Veldink, JH, Verbeek, WHM, Weersma, RK, Wolters, VM, Urcelay, E, Cukrowska, B, Greco, L, Neuhausen, SL, McManus, R, Barisani, D, Deloukas, P, Barrett, JC, Saavalainen, P, Wijmenga, C & Van Heel, DA 2010, 'Multiple common variants for celiac disease influencing immune gene expression', Nature Genetics, vol. 42, no. 4, pp. 295-302. https://doi.org/10.1038/ng.543

@article{ca10474067b543c4b625e0aab4402ad8,

title = "Multiple common variants for celiac disease influencing immune gene expression",

abstract = "We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with PGWAS<10-4 and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P combined 5 × 10 -8); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P<0.0028, FDR 5%) with cis gene expression.",

author = "Dubois, {Patrick C.A.} and Gosia Trynka and Lude Franke and Hunt, {Karen A.} and Jihane Romanos and Alessandra Curtotti and Alexandra Zhernakova and Heap, {Graham A.R.} and R{\'o}za {\'A}d{\'a}ny and Arpo Aromaa and Bardella, {Maria Teresa} and {Van Den Berg}, {Leonard H.} and Bockett, {Nicholas A.} and {De La Concha}, {Emilio G.} and B{\'a}rbara Dema and Fehrmann, {Rudolf S.N.} and Miguel Fern{\'a}ndez-Arquero and Szilvia Fiatal and Elvira Grandone and Green, {Peter M.} and Groen, {Harry J.M.} and Rhian Gwilliam and Houwen, {Roderick H.J.} and Hunt, {Sarah E.} and Katri Kaukinen and Dermot Kelleher and Ilma Korponay-Szabo and Kalle Kurppa and Padraic MacMathuna and Markku M{\"a}ki and Mazzilli, {Maria Cristina} and McCann, {Owen T.} and Mearin, {M. Luisa} and Mein, {Charles A.} and Mirza, {Muddassar M.} and Vanisha Mistry and Barbara Mora and Morley, {Katherine I.} and Mulder, {Chris J.} and Murray, {Joseph A.} and Concepci{\'o}n {\~N}ez and Elvira Oosterom and Ophoff, {Roel A.} and Isabel Polanco and Leena Peltonen and Mathieu Platteel and Anna Rybak and Veikko Salomaa and Schweizer, {Joachim J.} and Sperandeo, {Maria Pia} and Tack, {Greetje J.} and Graham Turner and Veldink, {Jan H.} and Verbeek, {Wieke H.M.} and Weersma, {Rinse K.} and Wolters, {Victorien M.} and Elena Urcelay and Bozena Cukrowska and Luigi Greco and Neuhausen, {Susan L.} and Ross McManus and Donatella Barisani and Panos Deloukas and Barrett, {Jeffrey C.} and Paivi Saavalainen and Cisca Wijmenga and {Van Heel}, {David A.}",

note = "Funding Information: We thank Coeliac UK for assistance with direct recruitment of individuals with celiac disease, and UK clinicians (L.C. Dinesen, G.K.T. Holmes, P.D. Howdle, J.R.F. Walters, D.S. Sanders, J. Swift, R. Crimmins, P. Kumar, D.P. Jewell, S.P.L. Travis and K. Moriarty) who recruited the celiac disease blood samples described in our previous studies1,22. We thank the genotyping facility of the UMCG (J. Smolonska and P. van der Vlies) for generating part of the GWAS and replication data and the gene expression data; R. Booij and M. Weenstra for preparation of Italian samples; H. Ahola, A. Heimonen, L. Koskinen, E. Einarsdottir and K. L{\"o}ytynoja for their work on Finnish sample collection, preparation and data handling; and E. Szathm{\'a}ri, J.B.Kov{\'a}cs, M. L{\"o}rincz and A. Nagy for their work with the Hungarian families. The Health2000 organization, Finrisk consortium, K. Mustalahti, M. Perola, K. Kristiansson and J. Koskinen are thanked for providing the Finnish control genotypes. We thank D.G. Clayton and N. Walker for providing T1DGC data in the required format. We thank the Irish Transfusion Service and Trinity College Dublin Biobank for control samples and V. Trimble, E. Close, G. Lawlor, A. Ryan, M. Abuzakouk, C. O{\textquoteright}Morain and G. Horgan for celiac disease sample collection and preparation We acknowledge DNA provided by Mayo Clinic Rochester and thank M. Bonamico and M. Barbato (Department of Paediatrics, Sapienza University of Rome, Italy) for recruiting individuals. We thank Polish clinicians for recruitment of individuals with celiac disease (Z. Domagala, A. Szaflarska-Poplawska, B. Oralewska, W. Cichy, B. Korczowski, K. Fryderek, E. Hapyn, K. Karczewska, A. Zalewska, I. Sakowska-Maliszewska, R. Mozrzymas, A. Zabka, M. Kolasa and B. Iwanczak). We thank M. Szperl for isolating DNA from blood samples provided by the Children{\textquoteright}s Memorial Health Institute (Warsaw, Poland). Dutch and UK genotyping for the second celiac disease GWAS was funded by the Wellcome Trust (084743 to D.A.v.H.). Italian genotyping for the second celiac disease GWAS was funded by the Coeliac Disease Consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative and partially funded by the Dutch Government (BSIK03009 to C.W.) and by the Netherlands Organisation for Scientific Research (NWO, VICI grant 918.66.620 to C.W.). E.G. is funded by the Italian Ministry of Healthy (grant RC2009). L.H.v.d.B. acknowledges funding from the Prinses Beatrix Fonds, the Adessium foundation and the Amyotrophic Lateral Sclerosis Association. L.F. received a Horizon Breakthrough grant from the Netherlands Genomics Initiative (93519031) and a VENI grant from NWO (ZonMW grant 916.10.135). P.C.A.D. is an MRC Clinical Training Fellow (G0700545). G.T. received a Ter Meulen Fund grant from the Royal Netherlands Academy of Arts and Sciences (KNAW). The gene expression study was funded in part by COPACETIC (EU grant 201379). This study makes use of data generated by the Wellcome Trust Case-Control Consortium 2 (WTCCC2). A full list of the WTCCC2 investigators who contributed to the generation of the data is available from http://www.wtccc.org.uk. Funding for the WTCCC2 project was provided by the Wellcome Trust under award 085475. This research utilizes resources provided by the Type 1 Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD) and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. We acknowledge the use of BRC Core Facilities provided by the financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy{\textquoteright}s & St. Thomas{\textquoteright} NHS Foundation Trust in partnership with King{\textquoteright}s College London and King{\textquoteright}s College Hospital NHS Foundation Trust. We acknowledge funding from the NIH: DK050678 and DK081645 (to S.L.N.), NS058980 (to R.A.O.); and DK57892 and DK071003 (to J.A.M.). The collection of Finnish and Hungarian subjects with celiac disease was funded by the EU Commission (MEXT-CT-2005-025270), the Academy of Finland, Hungarian Scientific Research Fund (contract OTKA 61868), the University of Helsinki Funds, the Competitive Research Funding of the Tampere University Hospital, the Foundation of Pediatric Research, the Sigrid Juselius Foundation and the Hungarian Academy of Sciences (2006TKI247 to R.A.). Funding for the collection and genotyping of the Polish samples was provided by UMC Cooperation Project (6/06/2006/NDON). R.M. is funded by Science Foundation Ireland. C. N{\'u}{\~n}ez has a FIS contract (CP08/0213). The Dublin Centre for Clinical Research contributed to collection of samples from affected individuals and is funded by the Irish Health Research Board and the Wellcome Trust. Finally, we thank all individuals with celiac disease and control individuals for participating in this study.",

year = "2010",

month = apr,

doi = "10.1038/ng.543",

language = "English (US)",

volume = "42",

pages = "295--302",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Multiple common variants for celiac disease influencing immune gene expression

AU - Dubois, Patrick C.A.

AU - Trynka, Gosia

AU - Franke, Lude

AU - Hunt, Karen A.

AU - Romanos, Jihane

AU - Curtotti, Alessandra

AU - Zhernakova, Alexandra

AU - Heap, Graham A.R.

AU - Ádány, Róza

AU - Aromaa, Arpo

AU - Bardella, Maria Teresa

AU - Van Den Berg, Leonard H.

AU - Bockett, Nicholas A.

AU - De La Concha, Emilio G.

AU - Dema, Bárbara

AU - Fehrmann, Rudolf S.N.

AU - Fernández-Arquero, Miguel

AU - Fiatal, Szilvia

AU - Grandone, Elvira

AU - Green, Peter M.

AU - Groen, Harry J.M.

AU - Gwilliam, Rhian

AU - Houwen, Roderick H.J.

AU - Hunt, Sarah E.

AU - Kaukinen, Katri

AU - Kelleher, Dermot

AU - Korponay-Szabo, Ilma

AU - Kurppa, Kalle

AU - MacMathuna, Padraic

AU - Mäki, Markku

AU - Mazzilli, Maria Cristina

AU - McCann, Owen T.

AU - Mearin, M. Luisa

AU - Mein, Charles A.

AU - Mirza, Muddassar M.

AU - Mistry, Vanisha

AU - Mora, Barbara

AU - Morley, Katherine I.

AU - Mulder, Chris J.

AU - Murray, Joseph A.

AU - Ñez, Concepción

AU - Oosterom, Elvira

AU - Ophoff, Roel A.

AU - Polanco, Isabel

AU - Peltonen, Leena

AU - Platteel, Mathieu

AU - Rybak, Anna

AU - Salomaa, Veikko

AU - Schweizer, Joachim J.

AU - Sperandeo, Maria Pia

AU - Tack, Greetje J.

AU - Turner, Graham

AU - Veldink, Jan H.

AU - Verbeek, Wieke H.M.

AU - Weersma, Rinse K.

AU - Wolters, Victorien M.

AU - Urcelay, Elena

AU - Cukrowska, Bozena

AU - Greco, Luigi

AU - Neuhausen, Susan L.

AU - McManus, Ross

AU - Barisani, Donatella

AU - Deloukas, Panos

AU - Barrett, Jeffrey C.

AU - Saavalainen, Paivi

AU - Wijmenga, Cisca

AU - Van Heel, David A.

N1 - Funding Information: We thank Coeliac UK for assistance with direct recruitment of individuals with celiac disease, and UK clinicians (L.C. Dinesen, G.K.T. Holmes, P.D. Howdle, J.R.F. Walters, D.S. Sanders, J. Swift, R. Crimmins, P. Kumar, D.P. Jewell, S.P.L. Travis and K. Moriarty) who recruited the celiac disease blood samples described in our previous studies1,22. We thank the genotyping facility of the UMCG (J. Smolonska and P. van der Vlies) for generating part of the GWAS and replication data and the gene expression data; R. Booij and M. Weenstra for preparation of Italian samples; H. Ahola, A. Heimonen, L. Koskinen, E. Einarsdottir and K. Löytynoja for their work on Finnish sample collection, preparation and data handling; and E. Szathmári, J.B.Kovács, M. Lörincz and A. Nagy for their work with the Hungarian families. The Health2000 organization, Finrisk consortium, K. Mustalahti, M. Perola, K. Kristiansson and J. Koskinen are thanked for providing the Finnish control genotypes. We thank D.G. Clayton and N. Walker for providing T1DGC data in the required format. We thank the Irish Transfusion Service and Trinity College Dublin Biobank for control samples and V. Trimble, E. Close, G. Lawlor, A. Ryan, M. Abuzakouk, C. O’Morain and G. Horgan for celiac disease sample collection and preparation We acknowledge DNA provided by Mayo Clinic Rochester and thank M. Bonamico and M. Barbato (Department of Paediatrics, Sapienza University of Rome, Italy) for recruiting individuals. We thank Polish clinicians for recruitment of individuals with celiac disease (Z. Domagala, A. Szaflarska-Poplawska, B. Oralewska, W. Cichy, B. Korczowski, K. Fryderek, E. Hapyn, K. Karczewska, A. Zalewska, I. Sakowska-Maliszewska, R. Mozrzymas, A. Zabka, M. Kolasa and B. Iwanczak). We thank M. Szperl for isolating DNA from blood samples provided by the Children’s Memorial Health Institute (Warsaw, Poland). Dutch and UK genotyping for the second celiac disease GWAS was funded by the Wellcome Trust (084743 to D.A.v.H.). Italian genotyping for the second celiac disease GWAS was funded by the Coeliac Disease Consortium, an Innovative Cluster approved by the Netherlands Genomics Initiative and partially funded by the Dutch Government (BSIK03009 to C.W.) and by the Netherlands Organisation for Scientific Research (NWO, VICI grant 918.66.620 to C.W.). E.G. is funded by the Italian Ministry of Healthy (grant RC2009). L.H.v.d.B. acknowledges funding from the Prinses Beatrix Fonds, the Adessium foundation and the Amyotrophic Lateral Sclerosis Association. L.F. received a Horizon Breakthrough grant from the Netherlands Genomics Initiative (93519031) and a VENI grant from NWO (ZonMW grant 916.10.135). P.C.A.D. is an MRC Clinical Training Fellow (G0700545). G.T. received a Ter Meulen Fund grant from the Royal Netherlands Academy of Arts and Sciences (KNAW). The gene expression study was funded in part by COPACETIC (EU grant 201379). This study makes use of data generated by the Wellcome Trust Case-Control Consortium 2 (WTCCC2). A full list of the WTCCC2 investigators who contributed to the generation of the data is available from http://www.wtccc.org.uk. Funding for the WTCCC2 project was provided by the Wellcome Trust under award 085475. This research utilizes resources provided by the Type 1 Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD) and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. We acknowledge the use of BRC Core Facilities provided by the financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St. Thomas’ NHS Foundation Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust. We acknowledge funding from the NIH: DK050678 and DK081645 (to S.L.N.), NS058980 (to R.A.O.); and DK57892 and DK071003 (to J.A.M.). The collection of Finnish and Hungarian subjects with celiac disease was funded by the EU Commission (MEXT-CT-2005-025270), the Academy of Finland, Hungarian Scientific Research Fund (contract OTKA 61868), the University of Helsinki Funds, the Competitive Research Funding of the Tampere University Hospital, the Foundation of Pediatric Research, the Sigrid Juselius Foundation and the Hungarian Academy of Sciences (2006TKI247 to R.A.). Funding for the collection and genotyping of the Polish samples was provided by UMC Cooperation Project (6/06/2006/NDON). R.M. is funded by Science Foundation Ireland. C. Núñez has a FIS contract (CP08/0213). The Dublin Centre for Clinical Research contributed to collection of samples from affected individuals and is funded by the Irish Health Research Board and the Wellcome Trust. Finally, we thank all individuals with celiac disease and control individuals for participating in this study.

PY - 2010/4

Y1 - 2010/4

N2 - We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with PGWAS<10-4 and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P combined 5 × 10 -8); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P<0.0028, FDR 5%) with cis gene expression.

AB - We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with PGWAS<10-4 and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P combined 5 × 10 -8); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 having key roles in thymic T-cell selection. There was evidence to suggest associations for a further 13 regions. In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P<0.0028, FDR 5%) with cis gene expression.

UR - http://www.scopus.com/inward/record.url?scp=77950243833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950243833&partnerID=8YFLogxK

U2 - 10.1038/ng.543

DO - 10.1038/ng.543

M3 - Article

C2 - 20190752

AN - SCOPUS:77950243833

SN - 1061-4036

VL - 42

SP - 295

EP - 302

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Multiple common variants for celiac disease influencing immune gene expression

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