Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes

Richard B. Kennedy, Inna G. Ovsyannikova, Iana H. Haralambieva, Megan M. O'Byrne, Robert M. Jacobson, V. Shane Pankratz, Gregory A. Poland

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Measles infection and vaccine response are complex biological processes that involve both viral and host genetic factors. We have previously investigated the influence of genetic polymorphisms on vaccine immune response, including measles vaccines, and have shown that polymorphisms in HLA, cytokine, cytokine receptor, and innate immune response genes are associated with variation in vaccine response but do not account for all of the inter-individual variance seen in vaccinated populations. In the current study we report the findings of a multigenic analysis of measles vaccine immunity, indicating a role for the measles virus receptor CD46, innate pattern-recognition receptors (DDX58, TLR2, 4, 5, 7 and 8) and intracellular signaling intermediates (MAP3K7, NFKBIA), and key antiviral molecules (VISA, OAS2, MX1, PKR) as well as cytokines (IFNA1, IL4, IL6, IL8, IL12B) and cytokine receptor genes (IL2RB, IL6R, IL8RA) in the genetic control of both humoral and cellular immune responses. This multivariate approach provided additional insights into the genetic control of measles vaccine responses over and above the information gained by our previous univariate SNP association analyses.

Original languageEnglish (US)
Pages (from-to)2159-2167
Number of pages9
JournalVaccine
Volume30
Issue number12
DOIs
StatePublished - Mar 9 2012

Keywords

  • Cytokines
  • Immunogenetics
  • Interferon response
  • Measles vaccine
  • Multigenic SNP association
  • Toll-like receptors
  • Vaccine response

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Kennedy, R. B., Ovsyannikova, I. G., Haralambieva, I. H., O'Byrne, M. M., Jacobson, R. M., Pankratz, V. S., & Poland, G. A. (2012). Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes. Vaccine, 30(12), 2159-2167. https://doi.org/10.1016/j.vaccine.2012.01.025