Multicentric focal acinar cell hyperplasia and hepatocyte-like cell metaplasia are induced by nitrosomethylurea in rat pancreas

Benito Mortis, Mirta A. Valentich, Raúl Urrutia, Marcelo Rivolta

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9 Scopus citations


The present report is a study of the effect of the carcinogen nitrosomethylurea (NMU) on pancreas of rats receiving during lifetime a lipid-poor diet, that is essential fatty acid deficient or control diets. Rats fed a commercial stock chow were mated. At day 10 of pregnancy, dams were divided into three groups, that were respectively supplied with the commercial chow, the essential fatty acid deficient or the sufficient diet. Each litter was separated at random in two groups that received at day one of life one intraperitoneal injection of NMU (50 mg/kg b.w.) or saline. After weaning, they were maintained for life with the diet that was supplied to their mothers. The pancreas of NMU-treated rats presented diffuse proliferative changes, focal acinar cell hyperplasias (FACH), and focal hepatocyte-like metaplasia (FHLCM). FACH were expansive presumably preneoplastic growths, showing abnormal differentiation. The number of NMU-treated rats bearing FACH and FHLCM did not significantly differ in the three nutritional conditions.

Original languageEnglish (US)
Pages (from-to)119-131
Number of pages13
JournalInternational Journal of Pancreatology
Issue number2
StatePublished - Feb 1991
Externally publishedYes



  • Chemical pancreatic tumorigenesis

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

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