TY - JOUR
T1 - Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma
AU - Chaichana, Kaisorn L.
AU - Pendleton, Courtney
AU - Chambless, Lola
AU - Camara-Quintana, Joaquin
AU - Nathan, Jay K.
AU - Hassam-Malani, Laila
AU - Li, Gordon
AU - Harsh IV, Griffith R.
AU - Thompson, Reid C.
AU - Lim, Michael
AU - Quinones-Hinojosa, Alfredo
PY - 2013/10
Y1 - 2013/10
N2 - Glioblastoma is the most common and aggressive type of primary brain tumor in adults. Average survival is approximately 1 year, but individual survival is heterogeneous. Using a single institutional experience, we have previously identified preoperative factors associated with survival and devised a prognostic scoring system based on these factors. The aims of the present study are to validate these preoperative factors and verify the efficacy of this scoring system using a multi-institutional cohort. Of the 334 patients in this study from three different institutions, the preoperative factors found to be negatively associated with survival in a Cox analysis were age >60 years (p < 0.0001), Karnofsky Performance Scale score ≤80 (p = 0.03), motor deficit (p = 0.02), language deficit (p = 0.04), and periventricular tumor location (p = 0.04). Patients possessing 0-1, 2, 3, and 4-5 of these variables were assigned a preoperative grade of 1, 2, 3, and 4, respectively. Patients with a preoperative grade of 1, 2, 3, and 4 had a median survival of 17.9, 12.3, 10, and 7.5 months, respectively. Survival of each of these grades was statistically significant (p < 0.05) in log-rank analysis. This grading system, based only on preoperative variables, may provide patients and physicians with prognostic information that may guide medical and surgical therapy before any intervention is pursued.
AB - Glioblastoma is the most common and aggressive type of primary brain tumor in adults. Average survival is approximately 1 year, but individual survival is heterogeneous. Using a single institutional experience, we have previously identified preoperative factors associated with survival and devised a prognostic scoring system based on these factors. The aims of the present study are to validate these preoperative factors and verify the efficacy of this scoring system using a multi-institutional cohort. Of the 334 patients in this study from three different institutions, the preoperative factors found to be negatively associated with survival in a Cox analysis were age >60 years (p < 0.0001), Karnofsky Performance Scale score ≤80 (p = 0.03), motor deficit (p = 0.02), language deficit (p = 0.04), and periventricular tumor location (p = 0.04). Patients possessing 0-1, 2, 3, and 4-5 of these variables were assigned a preoperative grade of 1, 2, 3, and 4, respectively. Patients with a preoperative grade of 1, 2, 3, and 4 had a median survival of 17.9, 12.3, 10, and 7.5 months, respectively. Survival of each of these grades was statistically significant (p < 0.05) in log-rank analysis. This grading system, based only on preoperative variables, may provide patients and physicians with prognostic information that may guide medical and surgical therapy before any intervention is pursued.
KW - Glioblastoma
KW - Prognosis
KW - Scoring system
KW - Surgery
KW - Survival
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U2 - 10.1016/j.jocn.2013.02.007
DO - 10.1016/j.jocn.2013.02.007
M3 - Article
C2 - 23928040
AN - SCOPUS:84885384833
SN - 0967-5868
VL - 20
SP - 1422
EP - 1426
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 10
ER -