Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma

Kaisorn L. Chaichana, Courtney Pendleton, Lola Chambless, Joaquin Camara-Quintana, Jay K. Nathan, Laila Hassam-Malani, Gordon Li, Griffith R. Harsh IV, Reid C. Thompson, Michael Lim, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Glioblastoma is the most common and aggressive type of primary brain tumor in adults. Average survival is approximately 1 year, but individual survival is heterogeneous. Using a single institutional experience, we have previously identified preoperative factors associated with survival and devised a prognostic scoring system based on these factors. The aims of the present study are to validate these preoperative factors and verify the efficacy of this scoring system using a multi-institutional cohort. Of the 334 patients in this study from three different institutions, the preoperative factors found to be negatively associated with survival in a Cox analysis were age >60 years (p < 0.0001), Karnofsky Performance Scale score ≤80 (p = 0.03), motor deficit (p = 0.02), language deficit (p = 0.04), and periventricular tumor location (p = 0.04). Patients possessing 0-1, 2, 3, and 4-5 of these variables were assigned a preoperative grade of 1, 2, 3, and 4, respectively. Patients with a preoperative grade of 1, 2, 3, and 4 had a median survival of 17.9, 12.3, 10, and 7.5 months, respectively. Survival of each of these grades was statistically significant (p < 0.05) in log-rank analysis. This grading system, based only on preoperative variables, may provide patients and physicians with prognostic information that may guide medical and surgical therapy before any intervention is pursued.

Original languageEnglish (US)
Pages (from-to)1422-1426
Number of pages5
JournalJournal of Clinical Neuroscience
Volume20
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

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Glioblastoma
Survival
Karnofsky Performance Status
Brain Neoplasms
Language
Physicians
Neoplasms

Keywords

  • Glioblastoma
  • Prognosis
  • Scoring system
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma. / Chaichana, Kaisorn L.; Pendleton, Courtney; Chambless, Lola; Camara-Quintana, Joaquin; Nathan, Jay K.; Hassam-Malani, Laila; Li, Gordon; Harsh IV, Griffith R.; Thompson, Reid C.; Lim, Michael; Quinones-Hinojosa, Alfredo.

In: Journal of Clinical Neuroscience, Vol. 20, No. 10, 10.2013, p. 1422-1426.

Research output: Contribution to journalArticle

Chaichana, KL, Pendleton, C, Chambless, L, Camara-Quintana, J, Nathan, JK, Hassam-Malani, L, Li, G, Harsh IV, GR, Thompson, RC, Lim, M & Quinones-Hinojosa, A 2013, 'Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma', Journal of Clinical Neuroscience, vol. 20, no. 10, pp. 1422-1426. https://doi.org/10.1016/j.jocn.2013.02.007
Chaichana, Kaisorn L. ; Pendleton, Courtney ; Chambless, Lola ; Camara-Quintana, Joaquin ; Nathan, Jay K. ; Hassam-Malani, Laila ; Li, Gordon ; Harsh IV, Griffith R. ; Thompson, Reid C. ; Lim, Michael ; Quinones-Hinojosa, Alfredo. / Multi-institutional validation of a preoperative scoring system which predicts survival for patients with glioblastoma. In: Journal of Clinical Neuroscience. 2013 ; Vol. 20, No. 10. pp. 1422-1426.
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