Mucosal ablation therapy of Barrett esophagus

Kenneth Ke Ning Wang, R. E. Sampliner

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Barrett esophagus is defined by the metaplasia of existing squamous mucosa into a specialized intestinal-type mucosa. The importance of this metaplasia is the association of this condition with the development of adenocarcinoma of the esophagus. Elimination of the metaplastic mucosa may decrease the cancer risk. Currently, several forms of therapy have evolved with the goal of replacing the specialized mucosa with normal squamous mucosa. These proposed treatments include photodynamic therapy and thermal techniques. The effectiveness of photodynamic therapy varies depending on the pharmaceutical photo-sensitizer used and the wavelength of light applied to activate the drug. Thermal techniques include multipolar coagulation, argon plasma coagulation, KTP:YAG laser therapy, Nd:YAG laser therapy, and argon laser therapy. Finally, mucosal resection has been attempted through the endoscope to remove large areas of the Barrett mucosa. All of these ablative strategies attempt to destroy the metaplastic mucosa and promote the regrowth of squamous epithelium. These therapies have demonstrated the ability to "reverse" the metaplasia to varying degrees, but a decrease in cancer risk has not been demonstrated conclusively with any of these treatment methods.

Original languageEnglish (US)
Pages (from-to)433-437
Number of pages5
JournalMayo Clinic Proceedings
Volume76
Issue number4
StatePublished - 2001

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Barrett Esophagus
Mucous Membrane
Solid-State Lasers
Metaplasia
Laser Therapy
Photochemotherapy
Therapeutics
Hot Temperature
Argon Plasma Coagulation
Argon
Endoscopes
Intestinal Mucosa
Pharmaceutical Preparations
Neoplasms
Epithelium
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mucosal ablation therapy of Barrett esophagus. / Wang, Kenneth Ke Ning; Sampliner, R. E.

In: Mayo Clinic Proceedings, Vol. 76, No. 4, 2001, p. 433-437.

Research output: Contribution to journalArticle

Wang, KKN & Sampliner, RE 2001, 'Mucosal ablation therapy of Barrett esophagus', Mayo Clinic Proceedings, vol. 76, no. 4, pp. 433-437.
Wang, Kenneth Ke Ning ; Sampliner, R. E. / Mucosal ablation therapy of Barrett esophagus. In: Mayo Clinic Proceedings. 2001 ; Vol. 76, No. 4. pp. 433-437.
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