MRI- and PET-based imaging markers for the diagnosis of Alzheimer's disease

Stefan Teipel, Reisa A. Sperling, Pawel Skudlarski, Clifford Jack, Harald Hampel, Andreas Fellgiebel, Karl Herholz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Imaging markers of early neurodegeneration play an important role for the definition of predementia and preclinical stages of Alzheimer's disease according to the newly proposed diagnostic consensus criteria. Markers of regional and global brain atrophy in MRI and the detection of cortical metabolic decline and cerebral amyloid deposition using PET are the best established imaging markers for prodromal and clinical Alzheimer's disease to date. Detection of structural and functional cortical disconnection using functional MRI and diffusion tensor imaging add to the diagnostic sensitivity and specificity. Important areas of future research are the application of imaging markers in large multicenter studies, and their implementation in radiological expert systems for diagnosis. Additionally, we need to consider the effect of these new markers on care for patients and counseling of at-risk subjects.

Original languageEnglish (US)
Title of host publicationAdvances in Biological Psychiatry
EditorsHarald hampel, Maria C. Carrillo
Number of pages35
StatePublished - Dec 5 2012

Publication series

NameAdvances in Biological Psychiatry
ISSN (Print)0378-7354
ISSN (Electronic)1662-2774

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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