MR elastography of the liver: Preliminary results

Olivier Rouvière, Meng Yin, M. Alex Dresner, Phillip J. Rossman, Lawrence J. Burgart, Jeff L. Fidler, Richard Lorne Ehman

Research output: Contribution to journalArticle

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Abstract

Purpose: To develop a method for measuring liver stiffness with magnetic resonance (MR) elastography and to prospectively test this technique in healthy volunteers and patients with liver fibrosis. Materials and Methods: This HIPAA-compliant study was approved by an institutional review board, and informed consent was obtained from each subject. First, to determine the feasibility of applying shear waves to the liver, a pneumatic acoustic wave generator was developed and tested by using a tissue-simulating gel phantom with ribs on one side and without ribs on the other. The effect of interposed ribs on stiffness measurements was tested. Then, liver stiffness was measured with MR elastography in 12 healthy volunteers (eight men, four women; mean age, 26.7 years; age range, 19-39 years) by using the subcostal approach and the transcostal approach and in 12 patients with chronic liver disease (six men, six women; mean age, 50.5 years; age range, 36-60 years) by using the transcostal approach. Various statistical analyses were performed to assess all measurements. Results: Ex vivo, interposed ribs reduced shear wave amplitude but did not hinder stiffness measurements. In volunteers, the transcostal approach surprisingly yielded better shear waves in the liver than did the subcostal approach. The mean liver shear stiffness was significantly lower in volunteers (mean, 2.0 kPa ± 0.3 [standard deviation]) than it was in patients with liver fibrosis (mean, 5.6 kPa ± 5.0; median, 3.7 kPa; range, 2.7-19.2 kPa; P < .001). Conclusion: MR elastography of the liver is feasible and shows promise as a quantitative method for noninvasive assessment of liver fibrosis.

Original languageEnglish (US)
Pages (from-to)440-448
Number of pages9
JournalRadiology
Volume240
Issue number2
DOIs
StatePublished - Aug 2006

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Elasticity Imaging Techniques
Ribs
Liver
Liver Cirrhosis
Volunteers
Healthy Volunteers
Health Insurance Portability and Accountability Act
Research Ethics Committees
Informed Consent
Liver Diseases
Chronic Disease
Gels

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Rouvière, O., Yin, M., Dresner, M. A., Rossman, P. J., Burgart, L. J., Fidler, J. L., & Ehman, R. L. (2006). MR elastography of the liver: Preliminary results. Radiology, 240(2), 440-448. https://doi.org/10.1148/radiol.2402050606

MR elastography of the liver : Preliminary results. / Rouvière, Olivier; Yin, Meng; Dresner, M. Alex; Rossman, Phillip J.; Burgart, Lawrence J.; Fidler, Jeff L.; Ehman, Richard Lorne.

In: Radiology, Vol. 240, No. 2, 08.2006, p. 440-448.

Research output: Contribution to journalArticle

Rouvière, O, Yin, M, Dresner, MA, Rossman, PJ, Burgart, LJ, Fidler, JL & Ehman, RL 2006, 'MR elastography of the liver: Preliminary results', Radiology, vol. 240, no. 2, pp. 440-448. https://doi.org/10.1148/radiol.2402050606
Rouvière O, Yin M, Dresner MA, Rossman PJ, Burgart LJ, Fidler JL et al. MR elastography of the liver: Preliminary results. Radiology. 2006 Aug;240(2):440-448. https://doi.org/10.1148/radiol.2402050606
Rouvière, Olivier ; Yin, Meng ; Dresner, M. Alex ; Rossman, Phillip J. ; Burgart, Lawrence J. ; Fidler, Jeff L. ; Ehman, Richard Lorne. / MR elastography of the liver : Preliminary results. In: Radiology. 2006 ; Vol. 240, No. 2. pp. 440-448.
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