@article{002bb6dc5fd2432886ba1097ef9f7327,
title = "Movement disorder society criteria for clinically established early Parkinson's disease",
abstract = "Background: In 2015, the International Parkinson and Movement Disorder Society published clinical diagnostic criteria for Parkinson's disease (PD). Although recent validation studies suggest high accuracy, one unmet need is for highly specific criteria for clinical trials in early/de novo PD. Objectives: The objective of this study was to generate and test a PD diagnostic criteria termed “clinically established early PD.”. Methods: We modified the Movement Disorder Society criteria to increase specificity for early PD by removing all disease duration components and changing red flags to absolute exclusions. We then estimated the sensitivity/specificity of clinically established early PD criteria in patients with disease duration <5 years, selected from a 626-patient validation study. Results: After documentation of parkinsonism, 18 individual exclusion criteria are assessed that preclude the diagnosis of “clinically established early PD.” Among 212 PD and 152 non-PD patients, the estimated specificity was 95.4%, with 69.8% sensitivity. Conclusions: We describe high-specificity criteria for de novo PD, which are freely available for use in clinical trials.",
keywords = "Parkinson's disease, criteria, diagnosis",
author = "Daniela Berg and Adler, {Charles H.} and Bloem, {Bastiaan R.} and Piu Chan and Thomas Gasser and Goetz, {Christopher G.} and Glenda Halliday and Lang, {Anthony E.} and Simon Lewis and Yuan Li and Inga Liepelt-Scarfone and Irene Litvan and Kenneth Marek and Corina Maetzler and Taomian Mi and Jos{\'e} Obeso and Wolfgang Oertel and Olanow, {C. Warren} and Werner Poewe and Silvia Rios-Romenets and Eva Sch{\"a}ffer and Klaus Seppi and Beatrice Heim and Elizabeth Slow and Matthew Stern and Bledsoe, {Ian O.} and G{\"u}nther Deuschl and Postuma, {Ronald B.}",
note = "Funding Information: 1Department of Neurology, Christian-Albrechts-University of Kiel, Kiel, Germany 2Department of Neurodegeneration, Hertie-Institute for Clinical Brain Research, T{\"u}bingen, Germany 3The Parkinson{\textquoteright}s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA 4Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands 5Xuanwu Hospital of Capitol of Medical University, Beijing, Peoples Republic of China 6Rush University Medical Center, Chicago, Illinois, USA 7Neuroscience Research Australia & University of New South Wales, Randwick, Australia 8Edmond J. Safra Program in Parkinson{\textquoteright}s Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada 9Brain and Mind Centre University of Sydney, Camperdown, Australia 10German Center for Neurodegenerative Diseases, T{\"u}bingen, Germany 11Department of Neurosciences, University of California San Diego, La Jolla, California, USA 12Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA 13University of Navarra-Fundaci{\'o}n para la Investigaci{\'o}n M{\'e}dica Aplicada (FIMA), Pamplona, Spain 14Department of Neurology, Philipps University of Marburg, Marburg, Germany 15Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA 16Department of Neurology, Innsbruck Medical University, Innsbruck, Austria 17Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada 18Penn Neurological Institute, Philadelphia, Pennsylvania, USA 19University of California, San Francisco, California, USA Publisher Copyright: {\textcopyright} 2018 International Parkinson and Movement Disorder Society",
year = "2018",
month = oct,
doi = "10.1002/mds.27431",
language = "English (US)",
volume = "33",
pages = "1643--1646",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "10",
}