Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion

R. Heddle, P. J. Collins, J. Dent, M. Horowitz, N. W. Read, B. Chatterton, L. A. Houghton

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The aim of this study was to define better the motor phenomena associated with the slowing of gastric emptying by a duodenal lipid infusion. Antral, pyloric and duodenal motility were recorded in 10 healthy subjects with a manometric assembly which incorporated multiple perfused side-holes and a sleeve sensor positioned astride the pylorus. The gastric emptying of a standard solid meal and the distribution of the ingesta between the proximal and distal stomach were monitored with a radionuclide technique. A triglyceride emulsion was infused into the duodenum for 45 min once 25% of the meal had emptied. The infusion caused significant slowing in the rate of gastric emptying (P <0.01). This slowing in gastric emptying was associated with the suppression of pressure waves in the distal antrum (P <0.01) and proximal duodenum (P <0.01), the induction of pressure waves isolated to a narrow pyloric segment (P <0.01), and a redistribution of ingesta from the distal to proximal stomach. These findings suggest that pressure waves isolated to the pylorus, changes in the intragastric distribution of ingested food, and changes in proximal duodenal motility may all act in concert with changes in antral motility to regulate the gastric emptying of solids.

Original languageEnglish (US)
Pages (from-to)437-447
Number of pages11
JournalJournal of Gastroenterology and Hepatology
Volume4
Issue number5
StatePublished - 1989
Externally publishedYes

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Gastric Emptying
Meals
Lipids
Pylorus
Duodenum
Pressure
Stomach
Emulsions
Radioisotopes
Healthy Volunteers
Triglycerides
Food
Antral

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Heddle, R., Collins, P. J., Dent, J., Horowitz, M., Read, N. W., Chatterton, B., & Houghton, L. A. (1989). Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. Journal of Gastroenterology and Hepatology, 4(5), 437-447.

Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. / Heddle, R.; Collins, P. J.; Dent, J.; Horowitz, M.; Read, N. W.; Chatterton, B.; Houghton, L. A.

In: Journal of Gastroenterology and Hepatology, Vol. 4, No. 5, 1989, p. 437-447.

Research output: Contribution to journalArticle

Heddle, R, Collins, PJ, Dent, J, Horowitz, M, Read, NW, Chatterton, B & Houghton, LA 1989, 'Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion', Journal of Gastroenterology and Hepatology, vol. 4, no. 5, pp. 437-447.
Heddle, R. ; Collins, P. J. ; Dent, J. ; Horowitz, M. ; Read, N. W. ; Chatterton, B. ; Houghton, L. A. / Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. In: Journal of Gastroenterology and Hepatology. 1989 ; Vol. 4, No. 5. pp. 437-447.
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